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Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China
Both Orthohantaviruses (HV) and Whenzhou Mammarenaviruses (WENV) are rodents borne viruses, allowing them to spread simultaneously in the same area and infect humans. To explore the potential threat of HV and WENV to public health safety, an environmental and laboratory investigation was conducted i...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371193/ https://www.ncbi.nlm.nih.gov/pubmed/37502398 http://dx.doi.org/10.3389/fmicb.2023.1225255 |
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author | Du, Shanshan Xie, Yun Deng, Xuefei Xia, Zhiyong Wu, Wei Huang, Xiaoxia Chen, Zhao Li, Aqian Li, Chuan Wang, Qin Sun, Lina Guo, Meijun Wang, Shiwen Liang, Mifang Li, Dexin Liu, Xiaoqing Li, Jiandong |
author_facet | Du, Shanshan Xie, Yun Deng, Xuefei Xia, Zhiyong Wu, Wei Huang, Xiaoxia Chen, Zhao Li, Aqian Li, Chuan Wang, Qin Sun, Lina Guo, Meijun Wang, Shiwen Liang, Mifang Li, Dexin Liu, Xiaoqing Li, Jiandong |
author_sort | Du, Shanshan |
collection | PubMed |
description | Both Orthohantaviruses (HV) and Whenzhou Mammarenaviruses (WENV) are rodents borne viruses, allowing them to spread simultaneously in the same area and infect humans. To explore the potential threat of HV and WENV to public health safety, an environmental and laboratory investigation was conducted in 2020–2021, in Jiangxi province, China. A total of 461 small mammals of 7 species and paired sera from 43 suspected HFRS cases were collected from Jiangxi Province, China. Viral genomic RNA and specific antibodies against HV and WENV were detected to evaluate the epidemic situation of the two viruses. Hantaan virus (HTNV), seoul virus (SEOV) and WENV RNA were detected in the lungs of the captured mammals, which resulted 4.1% and 7.4% of HV and WENV RNA positive respectively. Co-infections of WENV and SEOV were detected from Rattus norvegicus, Mus musculus and Rattus flavipectus with an overall co-infection rate of 0.65%. The detection rates of antibodies in the blood against HV and WENV were 11.9% (55/461), and 13.2% (61/461) respectively. The prevalence of viral infection and viral genetic characters varied among the selected areas. In the paired sera of 43 suspected HFRS cases, 38 were with HV infection, 11 were with WENV IgG, and 7 with a 4-fold or more of WENV IgG titer elevation. These results revealed the fact of the co-circulating and coinfection of HV and WENV in the same area at the same time, which might impact on public health safety. |
format | Online Article Text |
id | pubmed-10371193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103711932023-07-27 Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China Du, Shanshan Xie, Yun Deng, Xuefei Xia, Zhiyong Wu, Wei Huang, Xiaoxia Chen, Zhao Li, Aqian Li, Chuan Wang, Qin Sun, Lina Guo, Meijun Wang, Shiwen Liang, Mifang Li, Dexin Liu, Xiaoqing Li, Jiandong Front Microbiol Microbiology Both Orthohantaviruses (HV) and Whenzhou Mammarenaviruses (WENV) are rodents borne viruses, allowing them to spread simultaneously in the same area and infect humans. To explore the potential threat of HV and WENV to public health safety, an environmental and laboratory investigation was conducted in 2020–2021, in Jiangxi province, China. A total of 461 small mammals of 7 species and paired sera from 43 suspected HFRS cases were collected from Jiangxi Province, China. Viral genomic RNA and specific antibodies against HV and WENV were detected to evaluate the epidemic situation of the two viruses. Hantaan virus (HTNV), seoul virus (SEOV) and WENV RNA were detected in the lungs of the captured mammals, which resulted 4.1% and 7.4% of HV and WENV RNA positive respectively. Co-infections of WENV and SEOV were detected from Rattus norvegicus, Mus musculus and Rattus flavipectus with an overall co-infection rate of 0.65%. The detection rates of antibodies in the blood against HV and WENV were 11.9% (55/461), and 13.2% (61/461) respectively. The prevalence of viral infection and viral genetic characters varied among the selected areas. In the paired sera of 43 suspected HFRS cases, 38 were with HV infection, 11 were with WENV IgG, and 7 with a 4-fold or more of WENV IgG titer elevation. These results revealed the fact of the co-circulating and coinfection of HV and WENV in the same area at the same time, which might impact on public health safety. Frontiers Media S.A. 2023-07-12 /pmc/articles/PMC10371193/ /pubmed/37502398 http://dx.doi.org/10.3389/fmicb.2023.1225255 Text en Copyright © 2023 Du, Xie, Deng, Xia, Wu, Huang, Chen, Li, Li, Wang, Sun, Guo, Wang, Liang, Li, Liu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Du, Shanshan Xie, Yun Deng, Xuefei Xia, Zhiyong Wu, Wei Huang, Xiaoxia Chen, Zhao Li, Aqian Li, Chuan Wang, Qin Sun, Lina Guo, Meijun Wang, Shiwen Liang, Mifang Li, Dexin Liu, Xiaoqing Li, Jiandong Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China |
title | Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China |
title_full | Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China |
title_fullStr | Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China |
title_full_unstemmed | Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China |
title_short | Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China |
title_sort | co-circulation and co-infection of hantaviruses and wenzhou mammarenavirus in small mammals and humans in jiangxi, china |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371193/ https://www.ncbi.nlm.nih.gov/pubmed/37502398 http://dx.doi.org/10.3389/fmicb.2023.1225255 |
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