Cargando…

Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China

Both Orthohantaviruses (HV) and Whenzhou Mammarenaviruses (WENV) are rodents borne viruses, allowing them to spread simultaneously in the same area and infect humans. To explore the potential threat of HV and WENV to public health safety, an environmental and laboratory investigation was conducted i...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Shanshan, Xie, Yun, Deng, Xuefei, Xia, Zhiyong, Wu, Wei, Huang, Xiaoxia, Chen, Zhao, Li, Aqian, Li, Chuan, Wang, Qin, Sun, Lina, Guo, Meijun, Wang, Shiwen, Liang, Mifang, Li, Dexin, Liu, Xiaoqing, Li, Jiandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371193/
https://www.ncbi.nlm.nih.gov/pubmed/37502398
http://dx.doi.org/10.3389/fmicb.2023.1225255
_version_ 1785078102475407360
author Du, Shanshan
Xie, Yun
Deng, Xuefei
Xia, Zhiyong
Wu, Wei
Huang, Xiaoxia
Chen, Zhao
Li, Aqian
Li, Chuan
Wang, Qin
Sun, Lina
Guo, Meijun
Wang, Shiwen
Liang, Mifang
Li, Dexin
Liu, Xiaoqing
Li, Jiandong
author_facet Du, Shanshan
Xie, Yun
Deng, Xuefei
Xia, Zhiyong
Wu, Wei
Huang, Xiaoxia
Chen, Zhao
Li, Aqian
Li, Chuan
Wang, Qin
Sun, Lina
Guo, Meijun
Wang, Shiwen
Liang, Mifang
Li, Dexin
Liu, Xiaoqing
Li, Jiandong
author_sort Du, Shanshan
collection PubMed
description Both Orthohantaviruses (HV) and Whenzhou Mammarenaviruses (WENV) are rodents borne viruses, allowing them to spread simultaneously in the same area and infect humans. To explore the potential threat of HV and WENV to public health safety, an environmental and laboratory investigation was conducted in 2020–2021, in Jiangxi province, China. A total of 461 small mammals of 7 species and paired sera from 43 suspected HFRS cases were collected from Jiangxi Province, China. Viral genomic RNA and specific antibodies against HV and WENV were detected to evaluate the epidemic situation of the two viruses. Hantaan virus (HTNV), seoul virus (SEOV) and WENV RNA were detected in the lungs of the captured mammals, which resulted 4.1% and 7.4% of HV and WENV RNA positive respectively. Co-infections of WENV and SEOV were detected from Rattus norvegicus, Mus musculus and Rattus flavipectus with an overall co-infection rate of 0.65%. The detection rates of antibodies in the blood against HV and WENV were 11.9% (55/461), and 13.2% (61/461) respectively. The prevalence of viral infection and viral genetic characters varied among the selected areas. In the paired sera of 43 suspected HFRS cases, 38 were with HV infection, 11 were with WENV IgG, and 7 with a 4-fold or more of WENV IgG titer elevation. These results revealed the fact of the co-circulating and coinfection of HV and WENV in the same area at the same time, which might impact on public health safety.
format Online
Article
Text
id pubmed-10371193
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103711932023-07-27 Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China Du, Shanshan Xie, Yun Deng, Xuefei Xia, Zhiyong Wu, Wei Huang, Xiaoxia Chen, Zhao Li, Aqian Li, Chuan Wang, Qin Sun, Lina Guo, Meijun Wang, Shiwen Liang, Mifang Li, Dexin Liu, Xiaoqing Li, Jiandong Front Microbiol Microbiology Both Orthohantaviruses (HV) and Whenzhou Mammarenaviruses (WENV) are rodents borne viruses, allowing them to spread simultaneously in the same area and infect humans. To explore the potential threat of HV and WENV to public health safety, an environmental and laboratory investigation was conducted in 2020–2021, in Jiangxi province, China. A total of 461 small mammals of 7 species and paired sera from 43 suspected HFRS cases were collected from Jiangxi Province, China. Viral genomic RNA and specific antibodies against HV and WENV were detected to evaluate the epidemic situation of the two viruses. Hantaan virus (HTNV), seoul virus (SEOV) and WENV RNA were detected in the lungs of the captured mammals, which resulted 4.1% and 7.4% of HV and WENV RNA positive respectively. Co-infections of WENV and SEOV were detected from Rattus norvegicus, Mus musculus and Rattus flavipectus with an overall co-infection rate of 0.65%. The detection rates of antibodies in the blood against HV and WENV were 11.9% (55/461), and 13.2% (61/461) respectively. The prevalence of viral infection and viral genetic characters varied among the selected areas. In the paired sera of 43 suspected HFRS cases, 38 were with HV infection, 11 were with WENV IgG, and 7 with a 4-fold or more of WENV IgG titer elevation. These results revealed the fact of the co-circulating and coinfection of HV and WENV in the same area at the same time, which might impact on public health safety. Frontiers Media S.A. 2023-07-12 /pmc/articles/PMC10371193/ /pubmed/37502398 http://dx.doi.org/10.3389/fmicb.2023.1225255 Text en Copyright © 2023 Du, Xie, Deng, Xia, Wu, Huang, Chen, Li, Li, Wang, Sun, Guo, Wang, Liang, Li, Liu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Du, Shanshan
Xie, Yun
Deng, Xuefei
Xia, Zhiyong
Wu, Wei
Huang, Xiaoxia
Chen, Zhao
Li, Aqian
Li, Chuan
Wang, Qin
Sun, Lina
Guo, Meijun
Wang, Shiwen
Liang, Mifang
Li, Dexin
Liu, Xiaoqing
Li, Jiandong
Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China
title Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China
title_full Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China
title_fullStr Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China
title_full_unstemmed Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China
title_short Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China
title_sort co-circulation and co-infection of hantaviruses and wenzhou mammarenavirus in small mammals and humans in jiangxi, china
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371193/
https://www.ncbi.nlm.nih.gov/pubmed/37502398
http://dx.doi.org/10.3389/fmicb.2023.1225255
work_keys_str_mv AT dushanshan cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT xieyun cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT dengxuefei cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT xiazhiyong cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT wuwei cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT huangxiaoxia cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT chenzhao cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT liaqian cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT lichuan cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT wangqin cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT sunlina cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT guomeijun cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT wangshiwen cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT liangmifang cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT lidexin cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT liuxiaoqing cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina
AT lijiandong cocirculationandcoinfectionofhantavirusesandwenzhoumammarenavirusinsmallmammalsandhumansinjiangxichina