A 40-Year-Old Female With Mycobacterium abscessus Successfully Treated With a Dual Beta-Lactam Combination

Nontuberculous mycobacteria (NTM) infections are difficult to treat conditions, specially Mycobacterium abscessus (Mab) lung disease. The most recent ATS/ERS/ESCMID/IDSA clinical practice guidelines (2020) recommend regimens of multiple intravenous (IV) and oral antibiotics. Recent in vitro studies...

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Detalles Bibliográficos
Autores principales: Moguillansky, Natalia, DeSear, Kathryn, Dousa, Khalid M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371195/
https://www.ncbi.nlm.nih.gov/pubmed/37503487
http://dx.doi.org/10.7759/cureus.40993
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author Moguillansky, Natalia
DeSear, Kathryn
Dousa, Khalid M
author_facet Moguillansky, Natalia
DeSear, Kathryn
Dousa, Khalid M
author_sort Moguillansky, Natalia
collection PubMed
description Nontuberculous mycobacteria (NTM) infections are difficult to treat conditions, specially Mycobacterium abscessus (Mab) lung disease. The most recent ATS/ERS/ESCMID/IDSA clinical practice guidelines (2020) recommend regimens of multiple intravenous (IV) and oral antibiotics. Recent in vitro studies on M. abscessus show that the combination of two beta-lactam antibiotics, as well as select beta-lactamase inhibitors, provides significant synergy in its treatment. We present the first in vivo case of the successful treatment of Mycobacterium abscessus with imipenem and amoxicillin in addition to macrolides, clofazimine, and inhaled liposomal amikacin.
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spelling pubmed-103711952023-07-27 A 40-Year-Old Female With Mycobacterium abscessus Successfully Treated With a Dual Beta-Lactam Combination Moguillansky, Natalia DeSear, Kathryn Dousa, Khalid M Cureus Infectious Disease Nontuberculous mycobacteria (NTM) infections are difficult to treat conditions, specially Mycobacterium abscessus (Mab) lung disease. The most recent ATS/ERS/ESCMID/IDSA clinical practice guidelines (2020) recommend regimens of multiple intravenous (IV) and oral antibiotics. Recent in vitro studies on M. abscessus show that the combination of two beta-lactam antibiotics, as well as select beta-lactamase inhibitors, provides significant synergy in its treatment. We present the first in vivo case of the successful treatment of Mycobacterium abscessus with imipenem and amoxicillin in addition to macrolides, clofazimine, and inhaled liposomal amikacin. Cureus 2023-06-26 /pmc/articles/PMC10371195/ /pubmed/37503487 http://dx.doi.org/10.7759/cureus.40993 Text en Copyright © 2023, Moguillansky et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Infectious Disease
Moguillansky, Natalia
DeSear, Kathryn
Dousa, Khalid M
A 40-Year-Old Female With Mycobacterium abscessus Successfully Treated With a Dual Beta-Lactam Combination
title A 40-Year-Old Female With Mycobacterium abscessus Successfully Treated With a Dual Beta-Lactam Combination
title_full A 40-Year-Old Female With Mycobacterium abscessus Successfully Treated With a Dual Beta-Lactam Combination
title_fullStr A 40-Year-Old Female With Mycobacterium abscessus Successfully Treated With a Dual Beta-Lactam Combination
title_full_unstemmed A 40-Year-Old Female With Mycobacterium abscessus Successfully Treated With a Dual Beta-Lactam Combination
title_short A 40-Year-Old Female With Mycobacterium abscessus Successfully Treated With a Dual Beta-Lactam Combination
title_sort 40-year-old female with mycobacterium abscessus successfully treated with a dual beta-lactam combination
topic Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371195/
https://www.ncbi.nlm.nih.gov/pubmed/37503487
http://dx.doi.org/10.7759/cureus.40993
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