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Immune checkpoint activity regulates polycystic kidney disease progression

Innate and adaptive immune cells modulate the severity of autosomal dominant polycystic kidney disease (ADPKD), a common kidney disease with inadequate treatment options. ADPKD has parallels with cancer, in which immune checkpoint inhibitors have been shown to reactivate CD8(+) T cells and slow tumo...

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Detalles Bibliográficos
Autores principales:	Kleczko, Emily K., Nguyen, Dustin T., Marsh, Kenneth H., Bauer, Colin D., Li, Amy S., Monaghan, Marie-Louise T., Berger, Michael D., Furgeson, Seth B., Gitomer, Berenice Y., Chonchol, Michel B., Clambey, Eric T., Zimmerman, Kurt A., Nemenoff, Raphael A., Hopp, Katharina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371237/ https://www.ncbi.nlm.nih.gov/pubmed/37345660 http://dx.doi.org/10.1172/jci.insight.161318

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