Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy

Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults and remains an important public health issue worldwide. Here we demonstrate that the expression of stimulator of interferon genes (STING) is increased in patients with DR and animal models of diabetic eye disease. STING...

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Detalles Bibliográficos
Autores principales: Liu, Haitao, Ghosh, Sayan, Vaidya, Tanuja, Bammidi, Sridhar, Huang, Chao, Shang, Peng, Nair, Archana Padmanabhan, Chowdhury, Olivia, Stepicheva, Nadezda A., Strizhakova, Anastasia, Hose, Stacey, Mitrousis, Nikolaos, Gadde, Santosh Gopikrishna, MB, Thirumalesh, Strassburger, Pamela, Widmer, Gabriella, Lad, Eleonora M., Fort, Patrice E., Sahel, José-Alain, Zigler, J. Samuel, Sethu, Swaminathan, Westenskow, Peter D., Proia, Alan D., Sodhi, Akrit, Ghosh, Arkasubhra, Feenstra, Derrick, Sinha, Debasish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371250/
https://www.ncbi.nlm.nih.gov/pubmed/37345657
http://dx.doi.org/10.1172/jci.insight.168945

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