Cargando…
Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults
BACKGROUND: Older adults are recommended to receive influenza vaccination annually, and many use statins. Statins have immunomodulatory properties that might modify influenza vaccine effectiveness (VE) and alter influenza infection risk. METHODS: Using the test-negative design and linked laboratory...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371308/ https://www.ncbi.nlm.nih.gov/pubmed/36942534 http://dx.doi.org/10.1093/cid/ciad148 |
_version_ | 1785078119877574656 |
---|---|
author | Chung, Hannah Campitelli, Michael A Buchan, Sarah A Campigotto, Aaron Chen, Branson Crowcroft, Natasha S Dubey, Vinita Gubbay, Jonathan B Karnauchow, Timothy Katz, Kevin McGeer, Allison J McNally, J Dayre Mubareka, Samira Murti, Michelle Richardson, David C Rosella, Laura C Schwartz, Kevin L Smieja, Marek Zahariadis, George Kwong, Jeffrey C |
author_facet | Chung, Hannah Campitelli, Michael A Buchan, Sarah A Campigotto, Aaron Chen, Branson Crowcroft, Natasha S Dubey, Vinita Gubbay, Jonathan B Karnauchow, Timothy Katz, Kevin McGeer, Allison J McNally, J Dayre Mubareka, Samira Murti, Michelle Richardson, David C Rosella, Laura C Schwartz, Kevin L Smieja, Marek Zahariadis, George Kwong, Jeffrey C |
author_sort | Chung, Hannah |
collection | PubMed |
description | BACKGROUND: Older adults are recommended to receive influenza vaccination annually, and many use statins. Statins have immunomodulatory properties that might modify influenza vaccine effectiveness (VE) and alter influenza infection risk. METHODS: Using the test-negative design and linked laboratory and health administrative databases in Ontario, Canada, we estimated VE against laboratory-confirmed influenza among community-dwelling statin users and nonusers aged ≥66 years during the 2010–2011 to 2018–2019 influenza seasons. We also estimated the odds ratio for influenza infection comparing statin users and nonusers by vaccination status. RESULTS: Among persons tested for influenza across the 9 seasons, 54 243 had continuous statin exposure before testing and 48 469 were deemed unexposed. The VE against laboratory-confirmed influenza was similar between statin users and nonusers (17% [95% confidence interval, 13%–20%] and 17% [13%–21%] respectively; test for interaction, P = .87). In both vaccinated and unvaccinated persons, statin users had higher odds of laboratory-confirmed influenza than nonusers (odds ratios for vaccinated and unvaccinated persons 1.15 [95% confidence interval, 1.10–1.21] and 1.15 [1.10–1.20], respectively). These findings were consistent by mean daily dose and statin type. VE did not differ between users and nonusers of other cardiovascular drugs, except for β-blockers. We did not observe that vaccinated and unvaccinated users of these drugs had increased odds of influenza, except for unvaccinated β-blocker users. CONCLUSIONS: Influenza VE did not differ between statin users and nonusers. Statin use was associated with increased odds of laboratory-confirmed influenza in vaccinated and unvaccinated persons, but these associations might be affected by residual confounding. |
format | Online Article Text |
id | pubmed-10371308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103713082023-07-27 Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults Chung, Hannah Campitelli, Michael A Buchan, Sarah A Campigotto, Aaron Chen, Branson Crowcroft, Natasha S Dubey, Vinita Gubbay, Jonathan B Karnauchow, Timothy Katz, Kevin McGeer, Allison J McNally, J Dayre Mubareka, Samira Murti, Michelle Richardson, David C Rosella, Laura C Schwartz, Kevin L Smieja, Marek Zahariadis, George Kwong, Jeffrey C Clin Infect Dis Major Article BACKGROUND: Older adults are recommended to receive influenza vaccination annually, and many use statins. Statins have immunomodulatory properties that might modify influenza vaccine effectiveness (VE) and alter influenza infection risk. METHODS: Using the test-negative design and linked laboratory and health administrative databases in Ontario, Canada, we estimated VE against laboratory-confirmed influenza among community-dwelling statin users and nonusers aged ≥66 years during the 2010–2011 to 2018–2019 influenza seasons. We also estimated the odds ratio for influenza infection comparing statin users and nonusers by vaccination status. RESULTS: Among persons tested for influenza across the 9 seasons, 54 243 had continuous statin exposure before testing and 48 469 were deemed unexposed. The VE against laboratory-confirmed influenza was similar between statin users and nonusers (17% [95% confidence interval, 13%–20%] and 17% [13%–21%] respectively; test for interaction, P = .87). In both vaccinated and unvaccinated persons, statin users had higher odds of laboratory-confirmed influenza than nonusers (odds ratios for vaccinated and unvaccinated persons 1.15 [95% confidence interval, 1.10–1.21] and 1.15 [1.10–1.20], respectively). These findings were consistent by mean daily dose and statin type. VE did not differ between users and nonusers of other cardiovascular drugs, except for β-blockers. We did not observe that vaccinated and unvaccinated users of these drugs had increased odds of influenza, except for unvaccinated β-blocker users. CONCLUSIONS: Influenza VE did not differ between statin users and nonusers. Statin use was associated with increased odds of laboratory-confirmed influenza in vaccinated and unvaccinated persons, but these associations might be affected by residual confounding. Oxford University Press 2023-03-21 /pmc/articles/PMC10371308/ /pubmed/36942534 http://dx.doi.org/10.1093/cid/ciad148 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Major Article Chung, Hannah Campitelli, Michael A Buchan, Sarah A Campigotto, Aaron Chen, Branson Crowcroft, Natasha S Dubey, Vinita Gubbay, Jonathan B Karnauchow, Timothy Katz, Kevin McGeer, Allison J McNally, J Dayre Mubareka, Samira Murti, Michelle Richardson, David C Rosella, Laura C Schwartz, Kevin L Smieja, Marek Zahariadis, George Kwong, Jeffrey C Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults |
title | Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults |
title_full | Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults |
title_fullStr | Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults |
title_full_unstemmed | Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults |
title_short | Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults |
title_sort | evaluating the impact of statin use on influenza vaccine effectiveness and influenza infection in older adults |
topic | Major Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371308/ https://www.ncbi.nlm.nih.gov/pubmed/36942534 http://dx.doi.org/10.1093/cid/ciad148 |
work_keys_str_mv | AT chunghannah evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT campitellimichaela evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT buchansaraha evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT campigottoaaron evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT chenbranson evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT crowcroftnatashas evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT dubeyvinita evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT gubbayjonathanb evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT karnauchowtimothy evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT katzkevin evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT mcgeerallisonj evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT mcnallyjdayre evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT mubarekasamira evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT murtimichelle evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT richardsondavidc evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT rosellalaurac evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT schwartzkevinl evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT smiejamarek evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT zahariadisgeorge evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults AT kwongjeffreyc evaluatingtheimpactofstatinuseoninfluenzavaccineeffectivenessandinfluenzainfectioninolderadults |