Bile Cast Nephropathy Because of Acute Liver Injury Associated With Selective Androgen Receptor Modulators

Selective androgen receptor modulators (SARMs) are novel nonsteroidal agents abused for performance enhancement such as anabolic steroids. We report a case of a 27-year-old man who used 3 different SARMs and presented with progressive weakness. Initial laboratory testing showed kidney and liver inju...

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Autores principales: Arayangkool, Chinnawat, Gozun, Maan, Tanariyakul, Manasawee, Techasatian, Witina, Leesutipornchai, Thiratest, Nishimura, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371315/
https://www.ncbi.nlm.nih.gov/pubmed/37501938
http://dx.doi.org/10.14309/crj.0000000000001105
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author Arayangkool, Chinnawat
Gozun, Maan
Tanariyakul, Manasawee
Techasatian, Witina
Leesutipornchai, Thiratest
Nishimura, Yoshito
author_facet Arayangkool, Chinnawat
Gozun, Maan
Tanariyakul, Manasawee
Techasatian, Witina
Leesutipornchai, Thiratest
Nishimura, Yoshito
author_sort Arayangkool, Chinnawat
collection PubMed
description Selective androgen receptor modulators (SARMs) are novel nonsteroidal agents abused for performance enhancement such as anabolic steroids. We report a case of a 27-year-old man who used 3 different SARMs and presented with progressive weakness. Initial laboratory testing showed kidney and liver injury with creatinine 4.8 mg/dL and total bilirubin 43.3 mg/dL. An extensive workup was negative for other causes, and the results of liver and kidney biopsies were consistent with bile cast nephropathy because of SARM-associated drug-induced liver injury. His organ functions improved with the cessation of SARMs and plasmapheresis. Providers need to recognize the extreme consequences of SARM use.
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spelling pubmed-103713152023-07-27 Bile Cast Nephropathy Because of Acute Liver Injury Associated With Selective Androgen Receptor Modulators Arayangkool, Chinnawat Gozun, Maan Tanariyakul, Manasawee Techasatian, Witina Leesutipornchai, Thiratest Nishimura, Yoshito ACG Case Rep J Case Report Selective androgen receptor modulators (SARMs) are novel nonsteroidal agents abused for performance enhancement such as anabolic steroids. We report a case of a 27-year-old man who used 3 different SARMs and presented with progressive weakness. Initial laboratory testing showed kidney and liver injury with creatinine 4.8 mg/dL and total bilirubin 43.3 mg/dL. An extensive workup was negative for other causes, and the results of liver and kidney biopsies were consistent with bile cast nephropathy because of SARM-associated drug-induced liver injury. His organ functions improved with the cessation of SARMs and plasmapheresis. Providers need to recognize the extreme consequences of SARM use. Wolters Kluwer 2023-07-26 /pmc/articles/PMC10371315/ /pubmed/37501938 http://dx.doi.org/10.14309/crj.0000000000001105 Text en © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Arayangkool, Chinnawat
Gozun, Maan
Tanariyakul, Manasawee
Techasatian, Witina
Leesutipornchai, Thiratest
Nishimura, Yoshito
Bile Cast Nephropathy Because of Acute Liver Injury Associated With Selective Androgen Receptor Modulators
title Bile Cast Nephropathy Because of Acute Liver Injury Associated With Selective Androgen Receptor Modulators
title_full Bile Cast Nephropathy Because of Acute Liver Injury Associated With Selective Androgen Receptor Modulators
title_fullStr Bile Cast Nephropathy Because of Acute Liver Injury Associated With Selective Androgen Receptor Modulators
title_full_unstemmed Bile Cast Nephropathy Because of Acute Liver Injury Associated With Selective Androgen Receptor Modulators
title_short Bile Cast Nephropathy Because of Acute Liver Injury Associated With Selective Androgen Receptor Modulators
title_sort bile cast nephropathy because of acute liver injury associated with selective androgen receptor modulators
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371315/
https://www.ncbi.nlm.nih.gov/pubmed/37501938
http://dx.doi.org/10.14309/crj.0000000000001105
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