High-fat diet plus HNF1A variant promotes polyps by activating β-catenin in early-onset colorectal cancer

The incidence of early-onset colorectal cancer (EO-CRC) is rising and is poorly understood. Lifestyle factors and altered genetic background possibly contribute. Here, we performed targeted exon sequencing of archived leukocyte DNA from 158 EO-CRC participants, which identified a missense mutation a...

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Detalles Bibliográficos
Autores principales: Song, Heyu, Sontz, Ricky A., Vance, Matthew J., Morris, Julia M., Sheriff, Sulaiman, Zhu, Songli, Duan, Suzann, Zeng, Jiping, Koeppe, Erika, Pandey, Ritu, Thorne, Curtis A., Stoffel, Elena M., Merchant, Juanita L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371337/
https://www.ncbi.nlm.nih.gov/pubmed/37219942
http://dx.doi.org/10.1172/jci.insight.167163

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