A Syx-RhoA-Dia1 signaling axis regulates cell cycle progression, DNA damage, and therapy resistance in glioblastoma

Glioblastomas (GBM) are aggressive tumors that lack effective treatments. Here, we show that the Rho family guanine nucleotide exchange factor Syx promotes GBM cell growth both in vitro and in orthotopic xenografts derived from patients with GBM. Growth defects upon Syx depletion are attributed to p...

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Detalles Bibliográficos
Autores principales: Lin, Wan-Hsin, Feathers, Ryan W., Cooper, Lisa M., Lewis-Tuffin, Laura J., Chen, Jiaxiang, Sarkaria, Jann N., Anastasiadis, Panos Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371349/
https://www.ncbi.nlm.nih.gov/pubmed/37427593
http://dx.doi.org/10.1172/jci.insight.157491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371349/
https://www.ncbi.nlm.nih.gov/pubmed/37427593
http://dx.doi.org/10.1172/jci.insight.157491

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