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AGHmatrix: genetic relationship matrices in R

MOTIVATION: The resemble between relatives computed from pedigree and genomic data is an important resource for geneticists and ecologists, who are interested in understanding how genes influence phenotypic variation, fitness adaptation, and population dynamics. RESULTS: The AGHmatrix software is an...

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Autores principales: Amadeu, Rodrigo R, Garcia, Antonio Augusto F, Munoz, Patricio R, Ferrão, Luís Felipe V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371492/
https://www.ncbi.nlm.nih.gov/pubmed/37471595
http://dx.doi.org/10.1093/bioinformatics/btad445
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author Amadeu, Rodrigo R
Garcia, Antonio Augusto F
Munoz, Patricio R
Ferrão, Luís Felipe V
author_facet Amadeu, Rodrigo R
Garcia, Antonio Augusto F
Munoz, Patricio R
Ferrão, Luís Felipe V
author_sort Amadeu, Rodrigo R
collection PubMed
description MOTIVATION: The resemble between relatives computed from pedigree and genomic data is an important resource for geneticists and ecologists, who are interested in understanding how genes influence phenotypic variation, fitness adaptation, and population dynamics. RESULTS: The AGHmatrix software is an R package focused on the construction of pedigree (A matrix) and/or molecular markers (G matrix), with the possibility of building a combined matrix of pedigree corrected by molecular markers (H matrix). Designed to estimate the relationships for any ploidy level, the software also includes auxiliary functions related to filtering molecular markers, and checks pedigree errors in large data sets. After computing the relationship matrices, results from the AGHmatrix can be used in different contexts, including on prediction of (genomic) estimated breeding values and genome-wide association studies. AVAILABILITY AND IMPLEMENTATION: AGHmatrix v2.1.0 is available under GPL-3 license in CRAN at https://cran.r-project.org/web/packages/AGHmatrix/index.html and also in GitHub at https://github.com/rramadeu/AGHmatrix. It has a comprehensive tutorial, and it follows with real data examples.
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spelling pubmed-103714922023-07-27 AGHmatrix: genetic relationship matrices in R Amadeu, Rodrigo R Garcia, Antonio Augusto F Munoz, Patricio R Ferrão, Luís Felipe V Bioinformatics Applications Note MOTIVATION: The resemble between relatives computed from pedigree and genomic data is an important resource for geneticists and ecologists, who are interested in understanding how genes influence phenotypic variation, fitness adaptation, and population dynamics. RESULTS: The AGHmatrix software is an R package focused on the construction of pedigree (A matrix) and/or molecular markers (G matrix), with the possibility of building a combined matrix of pedigree corrected by molecular markers (H matrix). Designed to estimate the relationships for any ploidy level, the software also includes auxiliary functions related to filtering molecular markers, and checks pedigree errors in large data sets. After computing the relationship matrices, results from the AGHmatrix can be used in different contexts, including on prediction of (genomic) estimated breeding values and genome-wide association studies. AVAILABILITY AND IMPLEMENTATION: AGHmatrix v2.1.0 is available under GPL-3 license in CRAN at https://cran.r-project.org/web/packages/AGHmatrix/index.html and also in GitHub at https://github.com/rramadeu/AGHmatrix. It has a comprehensive tutorial, and it follows with real data examples. Oxford University Press 2023-07-20 /pmc/articles/PMC10371492/ /pubmed/37471595 http://dx.doi.org/10.1093/bioinformatics/btad445 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Applications Note
Amadeu, Rodrigo R
Garcia, Antonio Augusto F
Munoz, Patricio R
Ferrão, Luís Felipe V
AGHmatrix: genetic relationship matrices in R
title AGHmatrix: genetic relationship matrices in R
title_full AGHmatrix: genetic relationship matrices in R
title_fullStr AGHmatrix: genetic relationship matrices in R
title_full_unstemmed AGHmatrix: genetic relationship matrices in R
title_short AGHmatrix: genetic relationship matrices in R
title_sort aghmatrix: genetic relationship matrices in r
topic Applications Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371492/
https://www.ncbi.nlm.nih.gov/pubmed/37471595
http://dx.doi.org/10.1093/bioinformatics/btad445
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