C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment

The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell death. Cell free-double strand DNA (dsDNA) segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic GMP-AMP synthase (cGAS), which triggers robust activation of the innate immune...

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Detalles Bibliográficos
Autores principales: Zhu, Zhixin, Lu, Haipeng, Jin, Lulu, Gao, Yong, Qian, Zhefeng, Lu, Pan, Tong, Weijun, Lo, Pik Kwan, Mao, Zhengwei, Shi, Haifei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371767/
https://www.ncbi.nlm.nih.gov/pubmed/37502677
http://dx.doi.org/10.1016/j.bioactmat.2023.07.002

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