Cargando…
IgG4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection
IgG4 plasma cell neoplasm and myeloma are rare disease entities, not associated with systemic fibroinflammatory IgG4 related disease. We herein present a case of IgG4 plasma cell neoplasm in a liver transplant biopsy. A 55 year old female was treated with living donor transplant and had a complicate...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371806/ https://www.ncbi.nlm.nih.gov/pubmed/37521581 http://dx.doi.org/10.1016/j.lrr.2023.100379 |
_version_ | 1785078230075572224 |
---|---|
author | Bhalla, Amarpreet Liu, Qiang Fang, Yanan Lefkowitch, Jay H |
author_facet | Bhalla, Amarpreet Liu, Qiang Fang, Yanan Lefkowitch, Jay H |
author_sort | Bhalla, Amarpreet |
collection | PubMed |
description | IgG4 plasma cell neoplasm and myeloma are rare disease entities, not associated with systemic fibroinflammatory IgG4 related disease. We herein present a case of IgG4 plasma cell neoplasm in a liver transplant biopsy. A 55 year old female was treated with living donor transplant and had a complicated post-operative course. Three months post-transplant, she presented with small for size syndrome, biliary stricture, and inferior vena cava stenosis. Concomitant liver biopsy revealed mild acute cellular rejection with central perivenulitis pattern, and mild centrilobular fibrosis. She was treated with steroids which resulted in improvement of liver enzymes. Seven months post-transplant, she presented with subtherapeutic prograf levels and cholestatic pattern of elevated liver tests. ERCP revealed a stone which was removed. Hematological evaluation revealed an abnormal serum protein electrophoresis (SPEP). Monoclonal IgG kappa was elevated along with mildly elevated free Kappa/Lambda ratio. She was followed up and readmitted two months later for worsening liver function tests. The liver biopsy showed monotypic Kappa-and IgG4-restricted plasma cell infiltrates in portal, periportal, sinusoidal and centrilobular regions, compatible with plasma cell neoplasm. In the clinical context of positivity for a serum M-spike, the monoclonal hepatic infiltrates were deemed consistent with a Kappa-and IgG4-restricted plasma cell neoplasm. Patient was treated with pulsed steroids, and liver function tests subsequently downtrended. She was followed up by Hemoncology, and the treatment plan included carfilzomib-based induction therapy and dexamethasone to prevent end-organ damage from evolving myeloma. In the meanwhile, she developed acute appendicitis, underwent appendectomy, and passed away in the post-operative period. |
format | Online Article Text |
id | pubmed-10371806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103718062023-07-28 IgG4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection Bhalla, Amarpreet Liu, Qiang Fang, Yanan Lefkowitch, Jay H Leuk Res Rep Article IgG4 plasma cell neoplasm and myeloma are rare disease entities, not associated with systemic fibroinflammatory IgG4 related disease. We herein present a case of IgG4 plasma cell neoplasm in a liver transplant biopsy. A 55 year old female was treated with living donor transplant and had a complicated post-operative course. Three months post-transplant, she presented with small for size syndrome, biliary stricture, and inferior vena cava stenosis. Concomitant liver biopsy revealed mild acute cellular rejection with central perivenulitis pattern, and mild centrilobular fibrosis. She was treated with steroids which resulted in improvement of liver enzymes. Seven months post-transplant, she presented with subtherapeutic prograf levels and cholestatic pattern of elevated liver tests. ERCP revealed a stone which was removed. Hematological evaluation revealed an abnormal serum protein electrophoresis (SPEP). Monoclonal IgG kappa was elevated along with mildly elevated free Kappa/Lambda ratio. She was followed up and readmitted two months later for worsening liver function tests. The liver biopsy showed monotypic Kappa-and IgG4-restricted plasma cell infiltrates in portal, periportal, sinusoidal and centrilobular regions, compatible with plasma cell neoplasm. In the clinical context of positivity for a serum M-spike, the monoclonal hepatic infiltrates were deemed consistent with a Kappa-and IgG4-restricted plasma cell neoplasm. Patient was treated with pulsed steroids, and liver function tests subsequently downtrended. She was followed up by Hemoncology, and the treatment plan included carfilzomib-based induction therapy and dexamethasone to prevent end-organ damage from evolving myeloma. In the meanwhile, she developed acute appendicitis, underwent appendectomy, and passed away in the post-operative period. Elsevier 2023-07-08 /pmc/articles/PMC10371806/ /pubmed/37521581 http://dx.doi.org/10.1016/j.lrr.2023.100379 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Bhalla, Amarpreet Liu, Qiang Fang, Yanan Lefkowitch, Jay H IgG4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection |
title | IgG4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection |
title_full | IgG4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection |
title_fullStr | IgG4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection |
title_full_unstemmed | IgG4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection |
title_short | IgG4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection |
title_sort | igg4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371806/ https://www.ncbi.nlm.nih.gov/pubmed/37521581 http://dx.doi.org/10.1016/j.lrr.2023.100379 |
work_keys_str_mv | AT bhallaamarpreet igg4plasmacellneoplasminlivertransplantbiopsymasqueradingasrejection AT liuqiang igg4plasmacellneoplasminlivertransplantbiopsymasqueradingasrejection AT fangyanan igg4plasmacellneoplasminlivertransplantbiopsymasqueradingasrejection AT lefkowitchjayh igg4plasmacellneoplasminlivertransplantbiopsymasqueradingasrejection |