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Fractional flow reserve use in coronary artery revascularization: A systematic review and meta-analysis
Fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) is recommended in revascularization guidelines for intermediate lesions. However, recent studies comparing FFR-guided PCI with non-physiology-guided revascularization have reported conflicting results. PubMed and Embase we...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371824/ https://www.ncbi.nlm.nih.gov/pubmed/37520737 http://dx.doi.org/10.1016/j.isci.2023.107245 |
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author | Sanz Sánchez, Jorge Farjat Pasos, Julio I. Martinez Solé, Julia Hussain, Bilal Kumar, Sant Garg, Mohil Chiarito, Mauro Teira Calderón, Andrea Sorolla-Romero, Jose A. Echavarria Pinto, Mauro Shin, Eun-Seok Diez Gil, José Luis Waksman, Ron van de Hoef, Tim P. Garcia-Garcia, Hector M. |
author_facet | Sanz Sánchez, Jorge Farjat Pasos, Julio I. Martinez Solé, Julia Hussain, Bilal Kumar, Sant Garg, Mohil Chiarito, Mauro Teira Calderón, Andrea Sorolla-Romero, Jose A. Echavarria Pinto, Mauro Shin, Eun-Seok Diez Gil, José Luis Waksman, Ron van de Hoef, Tim P. Garcia-Garcia, Hector M. |
author_sort | Sanz Sánchez, Jorge |
collection | PubMed |
description | Fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) is recommended in revascularization guidelines for intermediate lesions. However, recent studies comparing FFR-guided PCI with non-physiology-guided revascularization have reported conflicting results. PubMed and Embase were searched for studies comparing FFR-guided PCI with non-physiology-guided revascularization strategies (angiography-guided, intracoronary imaging-guided, coronary artery bypass grafting). Data were pooled by meta-analysis using random-effects model. 26 studies enrolling 78,897 patients were included. FFR-guided PCI as compared to non-physiology-guided coronary revascularization had lower risk of all-cause mortality (odds ratio [OR] 0.79 95% confidence interval [CI] 0.64–0.99, I(2) = 53%) and myocardial infarction (MI) (OR 0.74 95% CI 0.59–0.93, I(2) = 44.7%). However, no differences between groups were found in terms of major adverse cardiac events (MACEs) (OR 0.86 95% CI 0.72–1.03, I(2) = 72.3%) and repeat revascularization (OR 1 95% CI 0.82–1.20, I(2) = 43.2%). Among patients with coronary artery disease (CAD), FFR-guided PCI as compared to non-physiology-guided revascularization was associated with a lower risk of all-cause mortality and MI. |
format | Online Article Text |
id | pubmed-10371824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103718242023-07-28 Fractional flow reserve use in coronary artery revascularization: A systematic review and meta-analysis Sanz Sánchez, Jorge Farjat Pasos, Julio I. Martinez Solé, Julia Hussain, Bilal Kumar, Sant Garg, Mohil Chiarito, Mauro Teira Calderón, Andrea Sorolla-Romero, Jose A. Echavarria Pinto, Mauro Shin, Eun-Seok Diez Gil, José Luis Waksman, Ron van de Hoef, Tim P. Garcia-Garcia, Hector M. iScience Article Fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) is recommended in revascularization guidelines for intermediate lesions. However, recent studies comparing FFR-guided PCI with non-physiology-guided revascularization have reported conflicting results. PubMed and Embase were searched for studies comparing FFR-guided PCI with non-physiology-guided revascularization strategies (angiography-guided, intracoronary imaging-guided, coronary artery bypass grafting). Data were pooled by meta-analysis using random-effects model. 26 studies enrolling 78,897 patients were included. FFR-guided PCI as compared to non-physiology-guided coronary revascularization had lower risk of all-cause mortality (odds ratio [OR] 0.79 95% confidence interval [CI] 0.64–0.99, I(2) = 53%) and myocardial infarction (MI) (OR 0.74 95% CI 0.59–0.93, I(2) = 44.7%). However, no differences between groups were found in terms of major adverse cardiac events (MACEs) (OR 0.86 95% CI 0.72–1.03, I(2) = 72.3%) and repeat revascularization (OR 1 95% CI 0.82–1.20, I(2) = 43.2%). Among patients with coronary artery disease (CAD), FFR-guided PCI as compared to non-physiology-guided revascularization was associated with a lower risk of all-cause mortality and MI. Elsevier 2023-07-03 /pmc/articles/PMC10371824/ /pubmed/37520737 http://dx.doi.org/10.1016/j.isci.2023.107245 Text en © 2023 The Authors. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sanz Sánchez, Jorge Farjat Pasos, Julio I. Martinez Solé, Julia Hussain, Bilal Kumar, Sant Garg, Mohil Chiarito, Mauro Teira Calderón, Andrea Sorolla-Romero, Jose A. Echavarria Pinto, Mauro Shin, Eun-Seok Diez Gil, José Luis Waksman, Ron van de Hoef, Tim P. Garcia-Garcia, Hector M. Fractional flow reserve use in coronary artery revascularization: A systematic review and meta-analysis |
title | Fractional flow reserve use in coronary artery revascularization: A systematic review and meta-analysis |
title_full | Fractional flow reserve use in coronary artery revascularization: A systematic review and meta-analysis |
title_fullStr | Fractional flow reserve use in coronary artery revascularization: A systematic review and meta-analysis |
title_full_unstemmed | Fractional flow reserve use in coronary artery revascularization: A systematic review and meta-analysis |
title_short | Fractional flow reserve use in coronary artery revascularization: A systematic review and meta-analysis |
title_sort | fractional flow reserve use in coronary artery revascularization: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371824/ https://www.ncbi.nlm.nih.gov/pubmed/37520737 http://dx.doi.org/10.1016/j.isci.2023.107245 |
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