Effect of the amount of cationic lipid used to complex siRNA on the cytotoxicity and proinflammatory activity of siRNA-solid lipid nanoparticles

When preparing siRNA-encapsulated solid lipid nanoparticles (siRNA-SLNs), cationic lipids are commonly included to condense and lipophilize the siRNA and thus increase its encapsulation in the SLNs. Unfortunately, cationic lipids also contribute significantly to the cytotoxicity and proinflammatory...

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Detalles Bibliográficos
Autores principales: Hanafy, Mahmoud S., Dao, Huy M., Xu, Haiyue, Koleng, John J., Sakran, Wedad, Cui, Zhengrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Special Issue on Pharmaceutical Technology in the America
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371828/
https://www.ncbi.nlm.nih.gov/pubmed/37521246
http://dx.doi.org/10.1016/j.ijpx.2023.100197

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