The biological interactions between kynurenine and AhR in melanocytes: in vitro studies

Kynurenine (KYN), a tryptophan metabolite, is endogenously produced by the skin cells and is present in human sweat. The aim of this study was to determine the molecular mechanism of the antiproliferative activity of KYN on human epidermal melanocytes. KYN significantly inhibited the metabolic activ...

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Autores principales: Walczak, Katarzyna, Szalast, Karolina, Krasowska, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371890/
https://www.ncbi.nlm.nih.gov/pubmed/37245164
http://dx.doi.org/10.1007/s00726-023-03279-0
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author Walczak, Katarzyna
Szalast, Karolina
Krasowska, Dorota
author_facet Walczak, Katarzyna
Szalast, Karolina
Krasowska, Dorota
author_sort Walczak, Katarzyna
collection PubMed
description Kynurenine (KYN), a tryptophan metabolite, is endogenously produced by the skin cells and is present in human sweat. The aim of this study was to determine the molecular mechanism of the antiproliferative activity of KYN on human epidermal melanocytes. KYN significantly inhibited the metabolic activity of HEMa cells by decreasing cyclin D1 and cyclin-dependent kinase 4 (CDK4) levels via the aryl hydrocarbon receptor (AhR) pathway. The results suggested that KYN might be involved in the regulation of physiological and pathological processes mediated by melanocytes.
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spelling pubmed-103718902023-07-28 The biological interactions between kynurenine and AhR in melanocytes: in vitro studies Walczak, Katarzyna Szalast, Karolina Krasowska, Dorota Amino Acids Short Communication Kynurenine (KYN), a tryptophan metabolite, is endogenously produced by the skin cells and is present in human sweat. The aim of this study was to determine the molecular mechanism of the antiproliferative activity of KYN on human epidermal melanocytes. KYN significantly inhibited the metabolic activity of HEMa cells by decreasing cyclin D1 and cyclin-dependent kinase 4 (CDK4) levels via the aryl hydrocarbon receptor (AhR) pathway. The results suggested that KYN might be involved in the regulation of physiological and pathological processes mediated by melanocytes. Springer Vienna 2023-05-28 2023 /pmc/articles/PMC10371890/ /pubmed/37245164 http://dx.doi.org/10.1007/s00726-023-03279-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Walczak, Katarzyna
Szalast, Karolina
Krasowska, Dorota
The biological interactions between kynurenine and AhR in melanocytes: in vitro studies
title The biological interactions between kynurenine and AhR in melanocytes: in vitro studies
title_full The biological interactions between kynurenine and AhR in melanocytes: in vitro studies
title_fullStr The biological interactions between kynurenine and AhR in melanocytes: in vitro studies
title_full_unstemmed The biological interactions between kynurenine and AhR in melanocytes: in vitro studies
title_short The biological interactions between kynurenine and AhR in melanocytes: in vitro studies
title_sort biological interactions between kynurenine and ahr in melanocytes: in vitro studies
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371890/
https://www.ncbi.nlm.nih.gov/pubmed/37245164
http://dx.doi.org/10.1007/s00726-023-03279-0
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