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The heterocellular heart: identities, interactions, and implications for cardiology
The heterocellular nature of the heart has been receiving increasing attention in recent years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes such as endothelial cells, fibroblasts, or immune cells are coming more into focus. The rise of single-cell sequencin...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371928/ https://www.ncbi.nlm.nih.gov/pubmed/37495826 http://dx.doi.org/10.1007/s00395-023-01000-6 |
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author | Lother, Achim Kohl, Peter |
author_facet | Lother, Achim Kohl, Peter |
author_sort | Lother, Achim |
collection | PubMed |
description | The heterocellular nature of the heart has been receiving increasing attention in recent years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes such as endothelial cells, fibroblasts, or immune cells are coming more into focus. The rise of single-cell sequencing technologies enables identification of ever more subtle differences and has reignited the question of what defines a cell’s identity. Here we provide an overview of the major cardiac cell types, describe their roles in homeostasis, and outline recent findings on non-canonical functions that may be of relevance for cardiology. We highlight modes of biochemical and biophysical interactions between different cardiac cell types and discuss the potential implications of the heterocellular nature of the heart for basic research and therapeutic interventions. |
format | Online Article Text |
id | pubmed-10371928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-103719282023-07-28 The heterocellular heart: identities, interactions, and implications for cardiology Lother, Achim Kohl, Peter Basic Res Cardiol Invited Review The heterocellular nature of the heart has been receiving increasing attention in recent years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes such as endothelial cells, fibroblasts, or immune cells are coming more into focus. The rise of single-cell sequencing technologies enables identification of ever more subtle differences and has reignited the question of what defines a cell’s identity. Here we provide an overview of the major cardiac cell types, describe their roles in homeostasis, and outline recent findings on non-canonical functions that may be of relevance for cardiology. We highlight modes of biochemical and biophysical interactions between different cardiac cell types and discuss the potential implications of the heterocellular nature of the heart for basic research and therapeutic interventions. Springer Berlin Heidelberg 2023-07-26 2023 /pmc/articles/PMC10371928/ /pubmed/37495826 http://dx.doi.org/10.1007/s00395-023-01000-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Invited Review Lother, Achim Kohl, Peter The heterocellular heart: identities, interactions, and implications for cardiology |
title | The heterocellular heart: identities, interactions, and implications for cardiology |
title_full | The heterocellular heart: identities, interactions, and implications for cardiology |
title_fullStr | The heterocellular heart: identities, interactions, and implications for cardiology |
title_full_unstemmed | The heterocellular heart: identities, interactions, and implications for cardiology |
title_short | The heterocellular heart: identities, interactions, and implications for cardiology |
title_sort | heterocellular heart: identities, interactions, and implications for cardiology |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371928/ https://www.ncbi.nlm.nih.gov/pubmed/37495826 http://dx.doi.org/10.1007/s00395-023-01000-6 |
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