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Numerical investigation of the dynamics of a rigid spherical particle in a vortical cross-slot flow at moderate inertia

The study of flow and particle dynamics in microfluidic cross-slot channels is of high relevance for lab-on-a-chip applications. In this work, we investigate the dynamics of a rigid spherical particle in a cross-slot junction for a channel height-to-width ratio of 0.6 and at a Reynolds number of 120...

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Autores principales: Kechagidis, Konstantinos, Owen, Benjamin, Guillou, Lionel, Tse, Henry, Di Carlo, Dino, Krüger, Timm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372015/
https://www.ncbi.nlm.nih.gov/pubmed/37519826
http://dx.doi.org/10.1038/s41378-023-00541-z
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author Kechagidis, Konstantinos
Owen, Benjamin
Guillou, Lionel
Tse, Henry
Di Carlo, Dino
Krüger, Timm
author_facet Kechagidis, Konstantinos
Owen, Benjamin
Guillou, Lionel
Tse, Henry
Di Carlo, Dino
Krüger, Timm
author_sort Kechagidis, Konstantinos
collection PubMed
description The study of flow and particle dynamics in microfluidic cross-slot channels is of high relevance for lab-on-a-chip applications. In this work, we investigate the dynamics of a rigid spherical particle in a cross-slot junction for a channel height-to-width ratio of 0.6 and at a Reynolds number of 120 for which a steady vortex exists in the junction area. Using an in-house immersed-boundary-lattice-Boltzmann code, we analyse the effect of the entry position of the particle in the junction and the particle size on the dynamics and trajectory shape of the particle. We find that the dynamics of the particle depend strongly on its lateral entry position in the junction and weakly on its vertical entry position; particles that enter close to the centre show trajectory oscillations. Larger particles have longer residence times in the junction and tend to oscillate less due to their confinement. Our work contributes to the understanding of particle dynamics in intersecting flows and enables the design of optimised geometries for cytometry and particle manipulation. [Image: see text]
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spelling pubmed-103720152023-07-28 Numerical investigation of the dynamics of a rigid spherical particle in a vortical cross-slot flow at moderate inertia Kechagidis, Konstantinos Owen, Benjamin Guillou, Lionel Tse, Henry Di Carlo, Dino Krüger, Timm Microsyst Nanoeng Article The study of flow and particle dynamics in microfluidic cross-slot channels is of high relevance for lab-on-a-chip applications. In this work, we investigate the dynamics of a rigid spherical particle in a cross-slot junction for a channel height-to-width ratio of 0.6 and at a Reynolds number of 120 for which a steady vortex exists in the junction area. Using an in-house immersed-boundary-lattice-Boltzmann code, we analyse the effect of the entry position of the particle in the junction and the particle size on the dynamics and trajectory shape of the particle. We find that the dynamics of the particle depend strongly on its lateral entry position in the junction and weakly on its vertical entry position; particles that enter close to the centre show trajectory oscillations. Larger particles have longer residence times in the junction and tend to oscillate less due to their confinement. Our work contributes to the understanding of particle dynamics in intersecting flows and enables the design of optimised geometries for cytometry and particle manipulation. [Image: see text] Nature Publishing Group UK 2023-07-26 /pmc/articles/PMC10372015/ /pubmed/37519826 http://dx.doi.org/10.1038/s41378-023-00541-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kechagidis, Konstantinos
Owen, Benjamin
Guillou, Lionel
Tse, Henry
Di Carlo, Dino
Krüger, Timm
Numerical investigation of the dynamics of a rigid spherical particle in a vortical cross-slot flow at moderate inertia
title Numerical investigation of the dynamics of a rigid spherical particle in a vortical cross-slot flow at moderate inertia
title_full Numerical investigation of the dynamics of a rigid spherical particle in a vortical cross-slot flow at moderate inertia
title_fullStr Numerical investigation of the dynamics of a rigid spherical particle in a vortical cross-slot flow at moderate inertia
title_full_unstemmed Numerical investigation of the dynamics of a rigid spherical particle in a vortical cross-slot flow at moderate inertia
title_short Numerical investigation of the dynamics of a rigid spherical particle in a vortical cross-slot flow at moderate inertia
title_sort numerical investigation of the dynamics of a rigid spherical particle in a vortical cross-slot flow at moderate inertia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372015/
https://www.ncbi.nlm.nih.gov/pubmed/37519826
http://dx.doi.org/10.1038/s41378-023-00541-z
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