Gasdermin D-mediated pyroptosis is regulated by AMPK-mediated phosphorylation in tumor cells

Gasdermin D (GSDMD) is a critical mediator of pyroptosis, which consists of a N-terminal pore-forming domain and a C-terminal autoinhibitory domain. Its cytolytic activity is sequestered by the intramolecular autoinhibitory mechanism. Upon caspase-1/11 mediated cleavage of GSDMD, the N-terminal pore...

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Detalles Bibliográficos
Autores principales: Chu, Xiufeng, Xiao, Xiang, Wang, Guangchuan, Uosef, Ahmed, Lou, Xiaohua, Arnold, Preston, Wang, Yixuan, Kong, Gangcheng, Wen, Mou, Minze, Laurie J., Li, Xian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372026/
https://www.ncbi.nlm.nih.gov/pubmed/37495617
http://dx.doi.org/10.1038/s41419-023-06013-6

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