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Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study
AIM: The aim of the study was to evaluate the changes in central vascular inflammation measured by FDG PET and myocardial blood flow reserve (MFR) determined by (82)Rb PET following therapy with biologic agents for 6 months in patients with psoriatic arthritis (PsA) and/or cutaneous psoriasis (PsO)...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372102/ https://www.ncbi.nlm.nih.gov/pubmed/36754934 http://dx.doi.org/10.1007/s12350-023-03204-8 |
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author | Boczar, Kevin E. Beanlands, Rob S. Glassman, Steven J. Wang, Jerry Zeng, Wanzhen deKemp, Robert A. Ward, Natalie C. Fehlmann, Christophe A. Wells, George A. Karsh, Jacob Dwivedi, Girish |
author_facet | Boczar, Kevin E. Beanlands, Rob S. Glassman, Steven J. Wang, Jerry Zeng, Wanzhen deKemp, Robert A. Ward, Natalie C. Fehlmann, Christophe A. Wells, George A. Karsh, Jacob Dwivedi, Girish |
author_sort | Boczar, Kevin E. |
collection | PubMed |
description | AIM: The aim of the study was to evaluate the changes in central vascular inflammation measured by FDG PET and myocardial blood flow reserve (MFR) determined by (82)Rb PET following therapy with biologic agents for 6 months in patients with psoriatic arthritis (PsA) and/or cutaneous psoriasis (PsO) (group 1) and compare with PsO subjects receiving non-biologic therapy (group 2) and controls (group 3). METHODS AND RESULTS: Target-to-background ratio (TBR) by FDG PET in the most diseased segment of the ascending aorta (TBR(max)) was measured to assess vascular inflammation. (82)Rb PET studies were used to assess changes in left ventricular MFR. A total of 34 participants were enrolled in the study (11 in group 1, 13 in group 2, and 10 controls). A significant drop in the thoracic aorta uptake was observed in the biologic-treated group (ΔTBR(max): − .46 ± .55) compared to the PsO group treated with non-biologic therapy (ΔTBR(max): .23 ± .67). Those showing response to biologic agents maintained MFR compared to who showed no response. CONCLUSION: In a cohort of psoriasis patients treated with biologics, FDG uptake in the thoracic aorta decreased over the study period. Patients who demonstrated a significant anti-inflammatory response on FDG PET imaging maintained their MFR compared to non-responders. |
format | Online Article Text |
id | pubmed-10372102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-103721022023-07-28 Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study Boczar, Kevin E. Beanlands, Rob S. Glassman, Steven J. Wang, Jerry Zeng, Wanzhen deKemp, Robert A. Ward, Natalie C. Fehlmann, Christophe A. Wells, George A. Karsh, Jacob Dwivedi, Girish J Nucl Cardiol Original Article AIM: The aim of the study was to evaluate the changes in central vascular inflammation measured by FDG PET and myocardial blood flow reserve (MFR) determined by (82)Rb PET following therapy with biologic agents for 6 months in patients with psoriatic arthritis (PsA) and/or cutaneous psoriasis (PsO) (group 1) and compare with PsO subjects receiving non-biologic therapy (group 2) and controls (group 3). METHODS AND RESULTS: Target-to-background ratio (TBR) by FDG PET in the most diseased segment of the ascending aorta (TBR(max)) was measured to assess vascular inflammation. (82)Rb PET studies were used to assess changes in left ventricular MFR. A total of 34 participants were enrolled in the study (11 in group 1, 13 in group 2, and 10 controls). A significant drop in the thoracic aorta uptake was observed in the biologic-treated group (ΔTBR(max): − .46 ± .55) compared to the PsO group treated with non-biologic therapy (ΔTBR(max): .23 ± .67). Those showing response to biologic agents maintained MFR compared to who showed no response. CONCLUSION: In a cohort of psoriasis patients treated with biologics, FDG uptake in the thoracic aorta decreased over the study period. Patients who demonstrated a significant anti-inflammatory response on FDG PET imaging maintained their MFR compared to non-responders. Springer International Publishing 2023-02-08 2023 /pmc/articles/PMC10372102/ /pubmed/36754934 http://dx.doi.org/10.1007/s12350-023-03204-8 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Boczar, Kevin E. Beanlands, Rob S. Glassman, Steven J. Wang, Jerry Zeng, Wanzhen deKemp, Robert A. Ward, Natalie C. Fehlmann, Christophe A. Wells, George A. Karsh, Jacob Dwivedi, Girish Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study |
title | Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study |
title_full | Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study |
title_fullStr | Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study |
title_full_unstemmed | Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study |
title_short | Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study |
title_sort | anti-inflammatory effect of biologic therapy in patients with psoriatic disease: a prospective cohort fdg pet study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372102/ https://www.ncbi.nlm.nih.gov/pubmed/36754934 http://dx.doi.org/10.1007/s12350-023-03204-8 |
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