Cargando…

Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants

Emerging SARS-CoV-2 variants, notably Omicron, continue to remain a formidable challenge to worldwide public health. The SARS-CoV-2 receptor-binding domain (RBD) is a hotspot for mutations, reflecting its critical role at the ACE2 interface during viral entry. Here, we comprehensively investigated t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haycroft, Ebene R., Davis, Samantha K., Ramanathan, Pradhipa, Lopez, Ester, Purcell, Ruth A., Tan, Li Lynn, Pymm, Phillip, Wines, Bruce D., Hogarth, P. Mark, Wheatley, Adam K., Juno, Jennifer A., Redmond, Samuel J., Gherardin, Nicholas A., Godfrey, Dale I., Tham, Wai-Hong, Selva, Kevin John, Kent, Stephen J., Chung, Amy W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372118/ https://www.ncbi.nlm.nih.gov/pubmed/37477828 http://dx.doi.org/10.1007/s00430-023-00773-w

Ejemplares similares

Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections
por: Selva, Kevin J., et al.
Publicado: (2023)

Heterologous SARS‐CoV‐2 IgA neutralising antibody responses in convalescent plasma
por: Davis, Samantha K, et al.
Publicado: (2022)

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
por: Wines, Bruce D., et al.
Publicado: (2022)

Corrigendum: Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
por: Wines, Bruce D., et al.
Publicado: (2023)

Decay of Fc-dependent antibody functions after mild to moderate COVID-19
por: Lee, Wen Shi, et al.
Publicado: (2021)

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay
por: Lopez, Ester, et al.
Publicado: (2021)

Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions
por: Lopez, Ester, et al.
Publicado: (2019)

Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2
por: Pymm, Phillip, et al.
Publicado: (2022)

Antibody glycosylation correlates with disease progression in SIV‐ Mycobacterium tuberculosis coinfected cynomolgus macaques
por: Haycroft, Ebene R, et al.
Publicado: (2023)

The Human FcγRII (CD32) Family of Leukocyte FcR in Health and Disease
por: Anania, Jessica C., et al.
Publicado: (2019)

Tear antibodies to SARS‐CoV‐2: implications for transmission
por: Selva, Kevin J, et al.
Publicado: (2021)

Reversal of the unique Q493R mutation increases the affinity of Omicron S1-RBD for ACE2
por: Philip, Angelin M., et al.
Publicado: (2023)

Bionics design of affinity peptide inhibitors for SARS-CoV-2 RBD to block SARS-CoV-2 RBD-ACE2 interactions
por: Liu, Xiaofeng, et al.
Publicado: (2023)

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice
por: Pymm, Phillip, et al.
Publicado: (2021)

Free Energy Perturbation Calculations of Mutation Effects on SARS-CoV-2 RBD::ACE2 Binding Affinity
por: Sergeeva, Alina P., et al.
Publicado: (2023)

Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2
por: Wines, Bruce D., et al.
Publicado: (2021)

Mutational scanning of spike RBD protein for enhanced ACE2 affinity emerging Southeast Asia in the late transmission phase
por: Kodchakorn, Kanchanok, et al.
Publicado: (2022)

Harnessing the immune system via FcγR function in immune therapy: a pathway to next‐gen mAbs
por: Chenoweth, Alicia M, et al.
Publicado: (2020)

Entropic contribution of ACE2 glycans to RBD binding
por: Mugnai, Mauro L., et al.
Publicado: (2023)

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics
por: Barton, Michael I, et al.
Publicado: (2021)

Antibody Functional Assays as Measures of Fc Receptor-Mediated Immunity to HIV - New Technologies and their Impact on the HIV Vaccine Field
por: Wines, Bruce D., et al.
Publicado: (2017)

Insilico study on the effect of SARS-CoV-2 RBD hotspot mutants’ interaction with ACE2 to understand the binding affinity and stability
por: Verma, Jyoti, et al.
Publicado: (2021)

Scanning the RBD-ACE2 molecular interactions in Omicron variant
por: Rath, Soumya Lipsa, et al.
Publicado: (2022)

hACE2 Fc-neutralization antibody cocktail provides synergistic protection against SARS-CoV-2 and its spike RBD variants
por: Liu, Junli, et al.
Publicado: (2021)

Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike RBD and human ACE2
por: Chen, Chen, et al.
Publicado: (2021)

SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2
por: Wu, Leyun, et al.
Publicado: (2022)

A CNN model for predicting binding affinity changes between SARS-CoV-2 spike RBD variants and ACE2 homologues
por: Chen, Chen, et al.
Publicado: (2022)

In silico study of intrinsic dynamics of full-length apo-ACE2 and RBD-ACE2 complex
por: Liu, Qing, et al.
Publicado: (2021)

Boosting of Markers of Fcγ Receptor Function in Anti-HIV Antibodies During Structured Treatment Interruption
por: Billings, Hugh, et al.
Publicado: (2019)

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain
por: Wheatley, Adam K., et al.
Publicado: (2021)

Human ACE2 orthologous peptide sequences show better binding affinity to SARS-CoV-2 RBD domain: Implications for drug design
por: Mahmoudi Azar, Lena, et al.
Publicado: (2023)

Exploring the disruption of SARS-CoV-2 RBD binding to hACE2
por: Carter, Camryn, et al.
Publicado: (2023)

S494 O-glycosylation site on the SARS-CoV-2 RBD affects the virus affinity to ACE2 and its infectivity; a molecular dynamics study
por: Rahnama, Shadi, et al.
Publicado: (2021)

Electrostatic Interactions Are the Primary Determinant of the Binding Affinity of SARS-CoV-2 Spike RBD to ACE2: A Computational Case Study of Omicron Variants
por: Sang, Peng, et al.
Publicado: (2022)

COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutants
por: Junker, Daniel, et al.
Publicado: (2022)

RBD Double Mutations of SARS-CoV-2 Strains Increase Transmissibility through Enhanced Interaction between RBD and ACE2 Receptor
por: Sinha, Siddharth, et al.
Publicado: (2021)

Characterization of Critical Determinants of ACE2–SARS CoV-2 RBD Interaction
por: Brown, Emily E. F., et al.
Publicado: (2021)

Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction
por: Lan, Jun, et al.
Publicado: (2022)

Cross-species binding spectrum of ACE2 to SARS-CoV-2 RBD
por: Liao, Xihao, et al.
Publicado: (2022)

Dimeric FcγR ectodomains detect pathogenic anti‐platelet factor 4–heparin antibodies in heparin‐induced thromobocytopenia
por: Wines, B. D., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_iif2rf2jdedn4aq9nc5d1gkree