A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy

The treatment of parathyroid hormone-related protein (PTHrP)-mediated hypercalcemia of malignancy includes treating the malignancy, intravenous fluids, and anti-resorptive therapies such as zoledronic acid or denosumab. PTHrP-mediated hypercalcemia has been reported in benign conditions such as syst...

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Autores principales: Niu, Isabella, Hsiao, Edward C., Wustrack, Rosanna, Wysolmerski, John J., Dann, Pamela, Masharani, Umesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372127/
https://www.ncbi.nlm.nih.gov/pubmed/37358786
http://dx.doi.org/10.1007/s00223-023-01099-8
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author Niu, Isabella
Hsiao, Edward C.
Wustrack, Rosanna
Wysolmerski, John J.
Dann, Pamela
Masharani, Umesh
author_facet Niu, Isabella
Hsiao, Edward C.
Wustrack, Rosanna
Wysolmerski, John J.
Dann, Pamela
Masharani, Umesh
author_sort Niu, Isabella
collection PubMed
description The treatment of parathyroid hormone-related protein (PTHrP)-mediated hypercalcemia of malignancy includes treating the malignancy, intravenous fluids, and anti-resorptive therapies such as zoledronic acid or denosumab. PTHrP-mediated hypercalcemia has been reported in benign conditions such as systemic lupus erythematous (SLE) and sarcoidosis and appears to be responsive to glucocorticoids. We report a case of PTHrP-induced hypercalcemia due to a malignancy—low grade fibromyxoid sarcoma—that responded to glucocorticoid treatment. This is the first report of glucocorticoids controlling PTHrP-mediated hypercalcemia of malignancy. Immunohistochemistry of the surgical pathology localized PTHrP staining to the vascular endothelial cells within the tumor. Further studies are needed to elucidate the mechanism of glucocorticoid action in the treatment of PTHrP-mediated hypercalcemia of malignancy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00223-023-01099-8.
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spelling pubmed-103721272023-07-28 A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy Niu, Isabella Hsiao, Edward C. Wustrack, Rosanna Wysolmerski, John J. Dann, Pamela Masharani, Umesh Calcif Tissue Int Case Reports The treatment of parathyroid hormone-related protein (PTHrP)-mediated hypercalcemia of malignancy includes treating the malignancy, intravenous fluids, and anti-resorptive therapies such as zoledronic acid or denosumab. PTHrP-mediated hypercalcemia has been reported in benign conditions such as systemic lupus erythematous (SLE) and sarcoidosis and appears to be responsive to glucocorticoids. We report a case of PTHrP-induced hypercalcemia due to a malignancy—low grade fibromyxoid sarcoma—that responded to glucocorticoid treatment. This is the first report of glucocorticoids controlling PTHrP-mediated hypercalcemia of malignancy. Immunohistochemistry of the surgical pathology localized PTHrP staining to the vascular endothelial cells within the tumor. Further studies are needed to elucidate the mechanism of glucocorticoid action in the treatment of PTHrP-mediated hypercalcemia of malignancy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00223-023-01099-8. Springer US 2023-06-26 2023 /pmc/articles/PMC10372127/ /pubmed/37358786 http://dx.doi.org/10.1007/s00223-023-01099-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Reports
Niu, Isabella
Hsiao, Edward C.
Wustrack, Rosanna
Wysolmerski, John J.
Dann, Pamela
Masharani, Umesh
A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy
title A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy
title_full A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy
title_fullStr A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy
title_full_unstemmed A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy
title_short A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy
title_sort case of hypercalcemia from pthrp-producing fibromyxoid sarcoma responsive to glucocorticoid therapy
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372127/
https://www.ncbi.nlm.nih.gov/pubmed/37358786
http://dx.doi.org/10.1007/s00223-023-01099-8
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