Development of rat duodenal monolayer model with effective barrier function from rat organoids for ADME assay

The in-depth analysis of the ADME profiles of drug candidates using in vitro models is essential for drug development since a drug’s exposure in humans depends on its ADME properties. In contrast to efforts in developing human in vitro absorption models, only a limited number of studies have explore...

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Detalles Bibliográficos
Autores principales: Tanaka, Kai, Kawai, Shigeto, Fujii, Etsuko, Yano, Masumi, Miyayama, Takashi, Nakano, Kiyotaka, Terao, Kimio, Suzuki, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372144/
https://www.ncbi.nlm.nih.gov/pubmed/37495742
http://dx.doi.org/10.1038/s41598-023-39425-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372144/
https://www.ncbi.nlm.nih.gov/pubmed/37495742
http://dx.doi.org/10.1038/s41598-023-39425-7

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