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Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism

Adriamycin (ADR) is an effective chemotherapy drug for various cancers but has serious side effects. ADR-induced liver damage is a common problem during therapy, but the underlying mechanism remains to be fully understood. In contrast, ADR-induced glomerular damage is well studied in rodents, and se...

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Detalles Bibliográficos
Autores principales: WATANABE, Masaki, KAKUTANI, Momoka, ANDO, Ryo, HIURA, Koki, SASAKI, Hayato, OKAMURA, Tadashi, SASAKI, Nobuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372250/
https://www.ncbi.nlm.nih.gov/pubmed/37245991
http://dx.doi.org/10.1292/jvms.23-0115
Descripción
Sumario:Adriamycin (ADR) is an effective chemotherapy drug for various cancers but has serious side effects. ADR-induced liver damage is a common problem during therapy, but the underlying mechanism remains to be fully understood. In contrast, ADR-induced glomerular damage is well studied in rodents, and sensitivity to ADR-induced nephropathy is because of the R2140C polymorphism of Prkdc gene. To investigate whether strain differences or sensitivity to ADR-induced liver damage are related to Prkdc polymorphism, this study compared the sensitivity to ADR-induced liver damage among C57BL/6J (B6J), B6-Prkdc(R2140C), and BALB/c mice. Although B6J exhibits resistance to ADR-induced liver injury, BALB/c and B6-Prkdc(R2140C) are more susceptible to liver injury, which is exacerbated by the presence of R2140C mutation in PRKDC.