Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism

Adriamycin (ADR) is an effective chemotherapy drug for various cancers but has serious side effects. ADR-induced liver damage is a common problem during therapy, but the underlying mechanism remains to be fully understood. In contrast, ADR-induced glomerular damage is well studied in rodents, and se...

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Autores principales: WATANABE, Masaki, KAKUTANI, Momoka, ANDO, Ryo, HIURA, Koki, SASAKI, Hayato, OKAMURA, Tadashi, SASAKI, Nobuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2023
Materias:
Laboratory Animal Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372250/
https://www.ncbi.nlm.nih.gov/pubmed/37245991
http://dx.doi.org/10.1292/jvms.23-0115
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author WATANABE, Masaki
KAKUTANI, Momoka
ANDO, Ryo
HIURA, Koki
SASAKI, Hayato
OKAMURA, Tadashi
SASAKI, Nobuya
author_facet WATANABE, Masaki
KAKUTANI, Momoka
ANDO, Ryo
HIURA, Koki
SASAKI, Hayato
OKAMURA, Tadashi
SASAKI, Nobuya
author_sort WATANABE, Masaki
collection PubMed
description Adriamycin (ADR) is an effective chemotherapy drug for various cancers but has serious side effects. ADR-induced liver damage is a common problem during therapy, but the underlying mechanism remains to be fully understood. In contrast, ADR-induced glomerular damage is well studied in rodents, and sensitivity to ADR-induced nephropathy is because of the R2140C polymorphism of Prkdc gene. To investigate whether strain differences or sensitivity to ADR-induced liver damage are related to Prkdc polymorphism, this study compared the sensitivity to ADR-induced liver damage among C57BL/6J (B6J), B6-Prkdc(R2140C), and BALB/c mice. Although B6J exhibits resistance to ADR-induced liver injury, BALB/c and B6-Prkdc(R2140C) are more susceptible to liver injury, which is exacerbated by the presence of R2140C mutation in PRKDC.
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spelling pubmed-103722502023-07-28 Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism WATANABE, Masaki KAKUTANI, Momoka ANDO, Ryo HIURA, Koki SASAKI, Hayato OKAMURA, Tadashi SASAKI, Nobuya J Vet Med Sci Laboratory Animal Science Adriamycin (ADR) is an effective chemotherapy drug for various cancers but has serious side effects. ADR-induced liver damage is a common problem during therapy, but the underlying mechanism remains to be fully understood. In contrast, ADR-induced glomerular damage is well studied in rodents, and sensitivity to ADR-induced nephropathy is because of the R2140C polymorphism of Prkdc gene. To investigate whether strain differences or sensitivity to ADR-induced liver damage are related to Prkdc polymorphism, this study compared the sensitivity to ADR-induced liver damage among C57BL/6J (B6J), B6-Prkdc(R2140C), and BALB/c mice. Although B6J exhibits resistance to ADR-induced liver injury, BALB/c and B6-Prkdc(R2140C) are more susceptible to liver injury, which is exacerbated by the presence of R2140C mutation in PRKDC. The Japanese Society of Veterinary Science 2023-05-29 2023-07 /pmc/articles/PMC10372250/ /pubmed/37245991 http://dx.doi.org/10.1292/jvms.23-0115 Text en ©2023 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Laboratory Animal Science
WATANABE, Masaki
KAKUTANI, Momoka
ANDO, Ryo
HIURA, Koki
SASAKI, Hayato
OKAMURA, Tadashi
SASAKI, Nobuya
Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism
title Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism
title_full Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism
title_fullStr Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism
title_full_unstemmed Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism
title_short Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism
title_sort susceptibility to adriamycin-induced hepatotoxicity in mice depends on prkdc polymorphism
topic Laboratory Animal Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372250/
https://www.ncbi.nlm.nih.gov/pubmed/37245991
http://dx.doi.org/10.1292/jvms.23-0115
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