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Oral pharmacokinetics of sulfadiazine and sulfamonomethoxine in female Holstein milking cows

The efficacy of orally administered drugs in cattle is thought to be slow because of the anatomical and physiological features of their forestomach. Thus, parenteral routes are mainly preferred to administer drugs. However, the effect of some drugs with unique physicochemical properties was promptly...

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Autores principales: TAJIMA, Tsuyoshi, SAIGA, Masumi, YAMAMOTO, Haru, ELBADAWY, Mohamed, ABUGOMAA, Amira, MIURA, Ryotaro, USUI, Tatsuya, SASAKI, Kazuaki, SHIMODA, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372257/
https://www.ncbi.nlm.nih.gov/pubmed/37225451
http://dx.doi.org/10.1292/jvms.23-0110
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author TAJIMA, Tsuyoshi
SAIGA, Masumi
YAMAMOTO, Haru
ELBADAWY, Mohamed
ABUGOMAA, Amira
MIURA, Ryotaro
USUI, Tatsuya
SASAKI, Kazuaki
SHIMODA, Minoru
author_facet TAJIMA, Tsuyoshi
SAIGA, Masumi
YAMAMOTO, Haru
ELBADAWY, Mohamed
ABUGOMAA, Amira
MIURA, Ryotaro
USUI, Tatsuya
SASAKI, Kazuaki
SHIMODA, Minoru
author_sort TAJIMA, Tsuyoshi
collection PubMed
description The efficacy of orally administered drugs in cattle is thought to be slow because of the anatomical and physiological features of their forestomach. Thus, parenteral routes are mainly preferred to administer drugs. However, the effect of some drugs with unique physicochemical properties was promptly obtained even after oral administration in clinically ill cattle. Therefore, the present study aimed to investigate pharmacokinetically the usefulness of the oral route in cattle by comparing the oral pharmacokinetic properties of two sulfonamides with different physicochemical properties. Sulfadiazine (SDZ) and sulfamonomethoxine (SMM) were administered by intravenous and oral route to four female Holstein cows with a 4-weeks washout period. Blood samples were collected over time, and SDZ and SMM concentrations in plasma were analyzed by HPLC. Data obtained from the same animal after intravenous and oral administration were simultaneously analyzed with the one compartment model, and kinetic parameters were calculated. The T(max) (mean ± SD) of SMM (2.75 ± 0.96 hr) was significantly achieved earlier than that of SDZ (5.00 ± 1.15 hr). Further, the mean absorption time of SMM (5.24 ± 0.69 hr) was significantly shorter than that of SDZ (5.92 ± 1.11 hr). Also, the half-life of absorption of SMM (3.91 ± 0.51 hr) was significantly shorter than that of SDZ (4.51 ± 0.82 hr). These data suggest that the absorption rates of highly unionized drugs (such as SMM) from the forestomach of cattle may be markedly higher than less unionized ones (such as SDZ).
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spelling pubmed-103722572023-07-28 Oral pharmacokinetics of sulfadiazine and sulfamonomethoxine in female Holstein milking cows TAJIMA, Tsuyoshi SAIGA, Masumi YAMAMOTO, Haru ELBADAWY, Mohamed ABUGOMAA, Amira MIURA, Ryotaro USUI, Tatsuya SASAKI, Kazuaki SHIMODA, Minoru J Vet Med Sci Pharmacology The efficacy of orally administered drugs in cattle is thought to be slow because of the anatomical and physiological features of their forestomach. Thus, parenteral routes are mainly preferred to administer drugs. However, the effect of some drugs with unique physicochemical properties was promptly obtained even after oral administration in clinically ill cattle. Therefore, the present study aimed to investigate pharmacokinetically the usefulness of the oral route in cattle by comparing the oral pharmacokinetic properties of two sulfonamides with different physicochemical properties. Sulfadiazine (SDZ) and sulfamonomethoxine (SMM) were administered by intravenous and oral route to four female Holstein cows with a 4-weeks washout period. Blood samples were collected over time, and SDZ and SMM concentrations in plasma were analyzed by HPLC. Data obtained from the same animal after intravenous and oral administration were simultaneously analyzed with the one compartment model, and kinetic parameters were calculated. The T(max) (mean ± SD) of SMM (2.75 ± 0.96 hr) was significantly achieved earlier than that of SDZ (5.00 ± 1.15 hr). Further, the mean absorption time of SMM (5.24 ± 0.69 hr) was significantly shorter than that of SDZ (5.92 ± 1.11 hr). Also, the half-life of absorption of SMM (3.91 ± 0.51 hr) was significantly shorter than that of SDZ (4.51 ± 0.82 hr). These data suggest that the absorption rates of highly unionized drugs (such as SMM) from the forestomach of cattle may be markedly higher than less unionized ones (such as SDZ). The Japanese Society of Veterinary Science 2023-05-24 2023-07 /pmc/articles/PMC10372257/ /pubmed/37225451 http://dx.doi.org/10.1292/jvms.23-0110 Text en ©2023 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pharmacology
TAJIMA, Tsuyoshi
SAIGA, Masumi
YAMAMOTO, Haru
ELBADAWY, Mohamed
ABUGOMAA, Amira
MIURA, Ryotaro
USUI, Tatsuya
SASAKI, Kazuaki
SHIMODA, Minoru
Oral pharmacokinetics of sulfadiazine and sulfamonomethoxine in female Holstein milking cows
title Oral pharmacokinetics of sulfadiazine and sulfamonomethoxine in female Holstein milking cows
title_full Oral pharmacokinetics of sulfadiazine and sulfamonomethoxine in female Holstein milking cows
title_fullStr Oral pharmacokinetics of sulfadiazine and sulfamonomethoxine in female Holstein milking cows
title_full_unstemmed Oral pharmacokinetics of sulfadiazine and sulfamonomethoxine in female Holstein milking cows
title_short Oral pharmacokinetics of sulfadiazine and sulfamonomethoxine in female Holstein milking cows
title_sort oral pharmacokinetics of sulfadiazine and sulfamonomethoxine in female holstein milking cows
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372257/
https://www.ncbi.nlm.nih.gov/pubmed/37225451
http://dx.doi.org/10.1292/jvms.23-0110
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