Cargando…

Intratumoral Air Bubbles and Hematemesis As Predictors of Pseudoaneurysm Rupture in Unresected Pancreatic Cancer

OBJECTIVE: Pseudoaneurysm rupture associated with unresected pancreatic cancer can cause rare but fatal hemobilia and gastrointestinal bleeding. This study aimed to identify factors predicting pseudoaneurysm rupture. METHODS: We conducted a single-center case-control study of unresected pancreatic c...

Descripción completa

Detalles Bibliográficos
Autores principales: Terada, Shuzo, Satoh, Tatsunori, Endo, Shinya, Hawke, Philip, Nakatani, Eiji, Sato, Yoko, Yamamoto, Takumi, Kawaguchi, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372266/
https://www.ncbi.nlm.nih.gov/pubmed/36384903
http://dx.doi.org/10.2169/internalmedicine.0856-22
_version_ 1785078335435440128
author Terada, Shuzo
Satoh, Tatsunori
Endo, Shinya
Hawke, Philip
Nakatani, Eiji
Sato, Yoko
Yamamoto, Takumi
Kawaguchi, Shinya
author_facet Terada, Shuzo
Satoh, Tatsunori
Endo, Shinya
Hawke, Philip
Nakatani, Eiji
Sato, Yoko
Yamamoto, Takumi
Kawaguchi, Shinya
author_sort Terada, Shuzo
collection PubMed
description OBJECTIVE: Pseudoaneurysm rupture associated with unresected pancreatic cancer can cause rare but fatal hemobilia and gastrointestinal bleeding. This study aimed to identify factors predicting pseudoaneurysm rupture. METHODS: We conducted a single-center case-control study of unresected pancreatic cancer patients treated at Shizuoka General Hospital between January 2011 and July 2020 using a retrospective cancer registry database. Included in the study were 611 consecutive patients with unresected pancreatic cancer, of whom 55 developed overt upper gastrointestinal bleeding or hemobilia. Twenty patients were excluded, as they had not undergone contrast-enhanced computed tomography (CT) or angiography. Patients were classified into pseudoaneurysm and non-pseudoaneurysm groups. One patient with arterial bleeding but without obvious pseudoaneurysm was included in the pseudoaneurysm group. Factors predicting pseudoaneurysm rupture at the onset of overt gastrointestinal bleeding were investigated using a logistic regression analysis. CT findings revealing air bubbles inside the tumor were described as intratumoral air bubbles. RESULTS: Thirty-five patients were included (15 in the pseudoaneurysm group, 20 in the non-pseudoaneurysm group). In the multivariate analysis, intratumoral air bubbles [odds ratio (OR), 12.9; 95% confidence interval (CI), 2.14-77.9; p=0.005] and hematemesis (OR, 6.30; 95% CI, 1.03-38.6; p=0.047) were independent predictors of pseudoaneurysm rupture. In addition, patients who experienced successful hemostasis and were re-administered chemotherapy survived more than six months. CONCLUSION: This study reveals that intratumoral air bubbles and hematemesis may predict pseudoaneurysm rupture at the onset of overt gastrointestinal bleeding. For patients presenting these findings, an examination with conventional or CT angiography may lead to an early diagnosis and improve the patient prognosis.
format Online
Article
Text
id pubmed-10372266
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-103722662023-07-28 Intratumoral Air Bubbles and Hematemesis As Predictors of Pseudoaneurysm Rupture in Unresected Pancreatic Cancer Terada, Shuzo Satoh, Tatsunori Endo, Shinya Hawke, Philip Nakatani, Eiji Sato, Yoko Yamamoto, Takumi Kawaguchi, Shinya Intern Med Original Article OBJECTIVE: Pseudoaneurysm rupture associated with unresected pancreatic cancer can cause rare but fatal hemobilia and gastrointestinal bleeding. This study aimed to identify factors predicting pseudoaneurysm rupture. METHODS: We conducted a single-center case-control study of unresected pancreatic cancer patients treated at Shizuoka General Hospital between January 2011 and July 2020 using a retrospective cancer registry database. Included in the study were 611 consecutive patients with unresected pancreatic cancer, of whom 55 developed overt upper gastrointestinal bleeding or hemobilia. Twenty patients were excluded, as they had not undergone contrast-enhanced computed tomography (CT) or angiography. Patients were classified into pseudoaneurysm and non-pseudoaneurysm groups. One patient with arterial bleeding but without obvious pseudoaneurysm was included in the pseudoaneurysm group. Factors predicting pseudoaneurysm rupture at the onset of overt gastrointestinal bleeding were investigated using a logistic regression analysis. CT findings revealing air bubbles inside the tumor were described as intratumoral air bubbles. RESULTS: Thirty-five patients were included (15 in the pseudoaneurysm group, 20 in the non-pseudoaneurysm group). In the multivariate analysis, intratumoral air bubbles [odds ratio (OR), 12.9; 95% confidence interval (CI), 2.14-77.9; p=0.005] and hematemesis (OR, 6.30; 95% CI, 1.03-38.6; p=0.047) were independent predictors of pseudoaneurysm rupture. In addition, patients who experienced successful hemostasis and were re-administered chemotherapy survived more than six months. CONCLUSION: This study reveals that intratumoral air bubbles and hematemesis may predict pseudoaneurysm rupture at the onset of overt gastrointestinal bleeding. For patients presenting these findings, an examination with conventional or CT angiography may lead to an early diagnosis and improve the patient prognosis. The Japanese Society of Internal Medicine 2022-11-16 2023-07-01 /pmc/articles/PMC10372266/ /pubmed/36384903 http://dx.doi.org/10.2169/internalmedicine.0856-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Terada, Shuzo
Satoh, Tatsunori
Endo, Shinya
Hawke, Philip
Nakatani, Eiji
Sato, Yoko
Yamamoto, Takumi
Kawaguchi, Shinya
Intratumoral Air Bubbles and Hematemesis As Predictors of Pseudoaneurysm Rupture in Unresected Pancreatic Cancer
title Intratumoral Air Bubbles and Hematemesis As Predictors of Pseudoaneurysm Rupture in Unresected Pancreatic Cancer
title_full Intratumoral Air Bubbles and Hematemesis As Predictors of Pseudoaneurysm Rupture in Unresected Pancreatic Cancer
title_fullStr Intratumoral Air Bubbles and Hematemesis As Predictors of Pseudoaneurysm Rupture in Unresected Pancreatic Cancer
title_full_unstemmed Intratumoral Air Bubbles and Hematemesis As Predictors of Pseudoaneurysm Rupture in Unresected Pancreatic Cancer
title_short Intratumoral Air Bubbles and Hematemesis As Predictors of Pseudoaneurysm Rupture in Unresected Pancreatic Cancer
title_sort intratumoral air bubbles and hematemesis as predictors of pseudoaneurysm rupture in unresected pancreatic cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372266/
https://www.ncbi.nlm.nih.gov/pubmed/36384903
http://dx.doi.org/10.2169/internalmedicine.0856-22
work_keys_str_mv AT teradashuzo intratumoralairbubblesandhematemesisaspredictorsofpseudoaneurysmruptureinunresectedpancreaticcancer
AT satohtatsunori intratumoralairbubblesandhematemesisaspredictorsofpseudoaneurysmruptureinunresectedpancreaticcancer
AT endoshinya intratumoralairbubblesandhematemesisaspredictorsofpseudoaneurysmruptureinunresectedpancreaticcancer
AT hawkephilip intratumoralairbubblesandhematemesisaspredictorsofpseudoaneurysmruptureinunresectedpancreaticcancer
AT nakatanieiji intratumoralairbubblesandhematemesisaspredictorsofpseudoaneurysmruptureinunresectedpancreaticcancer
AT satoyoko intratumoralairbubblesandhematemesisaspredictorsofpseudoaneurysmruptureinunresectedpancreaticcancer
AT yamamototakumi intratumoralairbubblesandhematemesisaspredictorsofpseudoaneurysmruptureinunresectedpancreaticcancer
AT kawaguchishinya intratumoralairbubblesandhematemesisaspredictorsofpseudoaneurysmruptureinunresectedpancreaticcancer