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Cryoglobulinemic Vasculitis Associated with Monoclonal Gammopathy of Undetermined Significance Developed after Sustained Virologic Response of Hepatitis C

A 72-year-old woman had a history of chronic hepatitis C virus (HCV) infection previously treated with interferon to achieve a sustained virologic response. Thereafter, she developed polyarthritis and purpura of the lower extremities as well as progressive renal dysfunction with hypertension and pro...

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Autores principales: Ishitoku, Michinori, Yoshida, Yusuke, Matsubara, Toshiki, Fujii, Kenji, Yorishima, Ai, Oka, Naoya, Masuda, Sho, Sugimoto, Tomohiro, Mokuda, Sho, Masaki, Takao, Hirata, Shintaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372272/
https://www.ncbi.nlm.nih.gov/pubmed/36384905
http://dx.doi.org/10.2169/internalmedicine.9768-22
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author Ishitoku, Michinori
Yoshida, Yusuke
Matsubara, Toshiki
Fujii, Kenji
Yorishima, Ai
Oka, Naoya
Masuda, Sho
Sugimoto, Tomohiro
Mokuda, Sho
Masaki, Takao
Hirata, Shintaro
author_facet Ishitoku, Michinori
Yoshida, Yusuke
Matsubara, Toshiki
Fujii, Kenji
Yorishima, Ai
Oka, Naoya
Masuda, Sho
Sugimoto, Tomohiro
Mokuda, Sho
Masaki, Takao
Hirata, Shintaro
author_sort Ishitoku, Michinori
collection PubMed
description A 72-year-old woman had a history of chronic hepatitis C virus (HCV) infection previously treated with interferon to achieve a sustained virologic response. Thereafter, she developed polyarthritis and purpura of the lower extremities as well as progressive renal dysfunction with hypertension and proteinuria that had occurred in the last three months. Laboratory investigations revealed seropositivity for cryoglobulin but negative findings for HCV RNA. She was ultimately diagnosed with cryoglobulinemic glomerulonephritis complicated by monoclonal gammopathy of undetermined significance (MGUS) based on the pathological findings of the kidney and bone marrow, indicating that MGUS-induced cryoglobulinemic vasculitis may occur even after HCV elimination.
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spelling pubmed-103722722023-07-28 Cryoglobulinemic Vasculitis Associated with Monoclonal Gammopathy of Undetermined Significance Developed after Sustained Virologic Response of Hepatitis C Ishitoku, Michinori Yoshida, Yusuke Matsubara, Toshiki Fujii, Kenji Yorishima, Ai Oka, Naoya Masuda, Sho Sugimoto, Tomohiro Mokuda, Sho Masaki, Takao Hirata, Shintaro Intern Med Case Report A 72-year-old woman had a history of chronic hepatitis C virus (HCV) infection previously treated with interferon to achieve a sustained virologic response. Thereafter, she developed polyarthritis and purpura of the lower extremities as well as progressive renal dysfunction with hypertension and proteinuria that had occurred in the last three months. Laboratory investigations revealed seropositivity for cryoglobulin but negative findings for HCV RNA. She was ultimately diagnosed with cryoglobulinemic glomerulonephritis complicated by monoclonal gammopathy of undetermined significance (MGUS) based on the pathological findings of the kidney and bone marrow, indicating that MGUS-induced cryoglobulinemic vasculitis may occur even after HCV elimination. The Japanese Society of Internal Medicine 2022-11-16 2023-07-01 /pmc/articles/PMC10372272/ /pubmed/36384905 http://dx.doi.org/10.2169/internalmedicine.9768-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ishitoku, Michinori
Yoshida, Yusuke
Matsubara, Toshiki
Fujii, Kenji
Yorishima, Ai
Oka, Naoya
Masuda, Sho
Sugimoto, Tomohiro
Mokuda, Sho
Masaki, Takao
Hirata, Shintaro
Cryoglobulinemic Vasculitis Associated with Monoclonal Gammopathy of Undetermined Significance Developed after Sustained Virologic Response of Hepatitis C
title Cryoglobulinemic Vasculitis Associated with Monoclonal Gammopathy of Undetermined Significance Developed after Sustained Virologic Response of Hepatitis C
title_full Cryoglobulinemic Vasculitis Associated with Monoclonal Gammopathy of Undetermined Significance Developed after Sustained Virologic Response of Hepatitis C
title_fullStr Cryoglobulinemic Vasculitis Associated with Monoclonal Gammopathy of Undetermined Significance Developed after Sustained Virologic Response of Hepatitis C
title_full_unstemmed Cryoglobulinemic Vasculitis Associated with Monoclonal Gammopathy of Undetermined Significance Developed after Sustained Virologic Response of Hepatitis C
title_short Cryoglobulinemic Vasculitis Associated with Monoclonal Gammopathy of Undetermined Significance Developed after Sustained Virologic Response of Hepatitis C
title_sort cryoglobulinemic vasculitis associated with monoclonal gammopathy of undetermined significance developed after sustained virologic response of hepatitis c
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372272/
https://www.ncbi.nlm.nih.gov/pubmed/36384905
http://dx.doi.org/10.2169/internalmedicine.9768-22
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