Cargando…
Ultrastructural skin alterations of healthy subjects with anti-desmoglein 1 antibodies in endemic areas to pemphigus foliaceus: A case series
BACKGROUND: Endemic pemphigus foliaceus and endemic pemphigus vulgaris are autoimmune dermatologic disorders endemic to the Peruvian Amazon. OBJECTIVE: To determine the ultrastructural skin alterations of three healthy subjects with anti DSG-1 antibodies in areas endemic to pemphigus foliaceus and p...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372304/ https://www.ncbi.nlm.nih.gov/pubmed/37520889 http://dx.doi.org/10.1016/j.jtauto.2023.100208 |
_version_ | 1785078344437465088 |
---|---|
author | Ramos, Willy Rojas, Nancy Ortega-Loayza, Alex G. Tello, Mercedes Jiménez, Gerardo Cuba-Cáceres, Nicolás Ronceros, Gerardo De La Cruz-Vargas, Jhony A. Vera-Ponce, Víctor Juan Guerrero, Nadia Gutierrez, Ericson L. |
author_facet | Ramos, Willy Rojas, Nancy Ortega-Loayza, Alex G. Tello, Mercedes Jiménez, Gerardo Cuba-Cáceres, Nicolás Ronceros, Gerardo De La Cruz-Vargas, Jhony A. Vera-Ponce, Víctor Juan Guerrero, Nadia Gutierrez, Ericson L. |
author_sort | Ramos, Willy |
collection | PubMed |
description | BACKGROUND: Endemic pemphigus foliaceus and endemic pemphigus vulgaris are autoimmune dermatologic disorders endemic to the Peruvian Amazon. OBJECTIVE: To determine the ultrastructural skin alterations of three healthy subjects with anti DSG-1 antibodies in areas endemic to pemphigus foliaceus and pemphigus vulgaris in the Peruvian Amazon. PATIENTS AND METHODS: Case series carried out from data of three clinically healthy subjects positive to anti DSG-1 antibodies, from Peru. This study consists of a sub-analysis of data gathered in a previous study. RESULTS: Ultrastructural results are presented from the skin biopsies of three clinically healthy patients positive to anti-desmoglein 1 (DSG-1) antibodies. High Resolution Optical Microscopy (HROM) showed the absence of acantholysis. Transmission Electron Microscopy (TEM) showed the widening of intercellular space between keratinocytes, the presence of vacuoles in intercellular space with granular material and cytoplasmic vacuolization, loss of desmosome structure, loss of normal distribution among tonofilaments and lateral separation among cells in the stratum basale. CONCLUSION: According to our results, healthy subjects that present anti-desmoglein 1 antibodies can develop ultrastructural alterations that are visible through transmission electron microscopy but not through conventional optical microscopy. |
format | Online Article Text |
id | pubmed-10372304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103723042023-07-28 Ultrastructural skin alterations of healthy subjects with anti-desmoglein 1 antibodies in endemic areas to pemphigus foliaceus: A case series Ramos, Willy Rojas, Nancy Ortega-Loayza, Alex G. Tello, Mercedes Jiménez, Gerardo Cuba-Cáceres, Nicolás Ronceros, Gerardo De La Cruz-Vargas, Jhony A. Vera-Ponce, Víctor Juan Guerrero, Nadia Gutierrez, Ericson L. J Transl Autoimmun Research paper BACKGROUND: Endemic pemphigus foliaceus and endemic pemphigus vulgaris are autoimmune dermatologic disorders endemic to the Peruvian Amazon. OBJECTIVE: To determine the ultrastructural skin alterations of three healthy subjects with anti DSG-1 antibodies in areas endemic to pemphigus foliaceus and pemphigus vulgaris in the Peruvian Amazon. PATIENTS AND METHODS: Case series carried out from data of three clinically healthy subjects positive to anti DSG-1 antibodies, from Peru. This study consists of a sub-analysis of data gathered in a previous study. RESULTS: Ultrastructural results are presented from the skin biopsies of three clinically healthy patients positive to anti-desmoglein 1 (DSG-1) antibodies. High Resolution Optical Microscopy (HROM) showed the absence of acantholysis. Transmission Electron Microscopy (TEM) showed the widening of intercellular space between keratinocytes, the presence of vacuoles in intercellular space with granular material and cytoplasmic vacuolization, loss of desmosome structure, loss of normal distribution among tonofilaments and lateral separation among cells in the stratum basale. CONCLUSION: According to our results, healthy subjects that present anti-desmoglein 1 antibodies can develop ultrastructural alterations that are visible through transmission electron microscopy but not through conventional optical microscopy. Elsevier 2023-07-13 /pmc/articles/PMC10372304/ /pubmed/37520889 http://dx.doi.org/10.1016/j.jtauto.2023.100208 Text en © 2023 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research paper Ramos, Willy Rojas, Nancy Ortega-Loayza, Alex G. Tello, Mercedes Jiménez, Gerardo Cuba-Cáceres, Nicolás Ronceros, Gerardo De La Cruz-Vargas, Jhony A. Vera-Ponce, Víctor Juan Guerrero, Nadia Gutierrez, Ericson L. Ultrastructural skin alterations of healthy subjects with anti-desmoglein 1 antibodies in endemic areas to pemphigus foliaceus: A case series |
title | Ultrastructural skin alterations of healthy subjects with anti-desmoglein 1 antibodies in endemic areas to pemphigus foliaceus: A case series |
title_full | Ultrastructural skin alterations of healthy subjects with anti-desmoglein 1 antibodies in endemic areas to pemphigus foliaceus: A case series |
title_fullStr | Ultrastructural skin alterations of healthy subjects with anti-desmoglein 1 antibodies in endemic areas to pemphigus foliaceus: A case series |
title_full_unstemmed | Ultrastructural skin alterations of healthy subjects with anti-desmoglein 1 antibodies in endemic areas to pemphigus foliaceus: A case series |
title_short | Ultrastructural skin alterations of healthy subjects with anti-desmoglein 1 antibodies in endemic areas to pemphigus foliaceus: A case series |
title_sort | ultrastructural skin alterations of healthy subjects with anti-desmoglein 1 antibodies in endemic areas to pemphigus foliaceus: a case series |
topic | Research paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372304/ https://www.ncbi.nlm.nih.gov/pubmed/37520889 http://dx.doi.org/10.1016/j.jtauto.2023.100208 |
work_keys_str_mv | AT ramoswilly ultrastructuralskinalterationsofhealthysubjectswithantidesmoglein1antibodiesinendemicareastopemphigusfoliaceusacaseseries AT rojasnancy ultrastructuralskinalterationsofhealthysubjectswithantidesmoglein1antibodiesinendemicareastopemphigusfoliaceusacaseseries AT ortegaloayzaalexg ultrastructuralskinalterationsofhealthysubjectswithantidesmoglein1antibodiesinendemicareastopemphigusfoliaceusacaseseries AT tellomercedes ultrastructuralskinalterationsofhealthysubjectswithantidesmoglein1antibodiesinendemicareastopemphigusfoliaceusacaseseries AT jimenezgerardo ultrastructuralskinalterationsofhealthysubjectswithantidesmoglein1antibodiesinendemicareastopemphigusfoliaceusacaseseries AT cubacaceresnicolas ultrastructuralskinalterationsofhealthysubjectswithantidesmoglein1antibodiesinendemicareastopemphigusfoliaceusacaseseries AT roncerosgerardo ultrastructuralskinalterationsofhealthysubjectswithantidesmoglein1antibodiesinendemicareastopemphigusfoliaceusacaseseries AT delacruzvargasjhonya ultrastructuralskinalterationsofhealthysubjectswithantidesmoglein1antibodiesinendemicareastopemphigusfoliaceusacaseseries AT veraponcevictorjuan ultrastructuralskinalterationsofhealthysubjectswithantidesmoglein1antibodiesinendemicareastopemphigusfoliaceusacaseseries AT guerreronadia ultrastructuralskinalterationsofhealthysubjectswithantidesmoglein1antibodiesinendemicareastopemphigusfoliaceusacaseseries AT gutierrezericsonl ultrastructuralskinalterationsofhealthysubjectswithantidesmoglein1antibodiesinendemicareastopemphigusfoliaceusacaseseries |