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Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana
This study focused on documenting and evaluating the cercaricidal activity of medicinal plants used for schistosomiasis treatment in an endemic area in Ghana. Through semistructured questionnaires, personal interviews with herbalists in communities surrounding the Barekese dam in the Atwima-Nwabiagy...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372336/ https://www.ncbi.nlm.nih.gov/pubmed/37520159 http://dx.doi.org/10.1155/2023/6707157 |
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author | Asante-Kwatia, Evelyn Gyimah, Lord Forkuo, Arnold Donkor Anyan, William Kofi Gbemu, Makafui Adzo Armah, Francis Ackah Mensah, Abraham Yeboah |
author_facet | Asante-Kwatia, Evelyn Gyimah, Lord Forkuo, Arnold Donkor Anyan, William Kofi Gbemu, Makafui Adzo Armah, Francis Ackah Mensah, Abraham Yeboah |
author_sort | Asante-Kwatia, Evelyn |
collection | PubMed |
description | This study focused on documenting and evaluating the cercaricidal activity of medicinal plants used for schistosomiasis treatment in an endemic area in Ghana. Through semistructured questionnaires, personal interviews with herbalists in communities surrounding the Barekese dam in the Atwima-Nwabiagya district, where the disease is endemic, were carried out. Thirty medicinal plants distributed in 19 families were reported to be used for schistosomiasis treatment in the survey. Information on the plants, including scientific names, common names, families, and the used plant part were recorded. The families Apocynaceae and Euphorbiaceae recorded the highest number of plants (14% each), followed by Asteraceae (10%), Loranthaceae (7%), and Rubiaceae (7%). In vitro cercaricidal activity of methanol extracts of nine out of the thirty plants was performed by exposing human Schistosoma mansoni cercariae obtained from Biomphalaria pfeifferi to various concentrations of extracts over a duration of 240 minutes. All the plants tested demonstrated time- and concentration-dependent cercaricidal activity. With lethality being set at <1000 μg/mL, the cercaricidal activity in order of decreasing potency was as follows: Withania somnifera (LC(50) = 1.29) > Balanites aegyptiaca (LC(50) = 7.1) > Xylia evansii (LC(50) = 11.14) > Jathropha multifida (LC(50) = 12.9) > Justicia flava (LC(50) = 22.9) > Anopyxis klaineana (LC(50) = 182.81) > Ximenia americana (LC(50) = 194.98) > Loranthus lecardii (LC(50) = 223.87) > Bridelia tenufolia (LC(50) = 309.03) > Zanthoxylium zanthoxyloides (LC(50) = 851.94). Phytochemicals, including alkaloids, tannins, triterpenes, saponins, phytosterols, and flavonoids were identified in the plants. The result of this study gives scientific credence to the traditional use of these plants in the treatment of schistosomiasis and proves that the rich botanical knowledge of medicinal plants provides an incredible starting point for the discovery of new anti-schistosomal drugs for the local population. |
format | Online Article Text |
id | pubmed-10372336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-103723362023-07-28 Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana Asante-Kwatia, Evelyn Gyimah, Lord Forkuo, Arnold Donkor Anyan, William Kofi Gbemu, Makafui Adzo Armah, Francis Ackah Mensah, Abraham Yeboah J Parasitol Res Research Article This study focused on documenting and evaluating the cercaricidal activity of medicinal plants used for schistosomiasis treatment in an endemic area in Ghana. Through semistructured questionnaires, personal interviews with herbalists in communities surrounding the Barekese dam in the Atwima-Nwabiagya district, where the disease is endemic, were carried out. Thirty medicinal plants distributed in 19 families were reported to be used for schistosomiasis treatment in the survey. Information on the plants, including scientific names, common names, families, and the used plant part were recorded. The families Apocynaceae and Euphorbiaceae recorded the highest number of plants (14% each), followed by Asteraceae (10%), Loranthaceae (7%), and Rubiaceae (7%). In vitro cercaricidal activity of methanol extracts of nine out of the thirty plants was performed by exposing human Schistosoma mansoni cercariae obtained from Biomphalaria pfeifferi to various concentrations of extracts over a duration of 240 minutes. All the plants tested demonstrated time- and concentration-dependent cercaricidal activity. With lethality being set at <1000 μg/mL, the cercaricidal activity in order of decreasing potency was as follows: Withania somnifera (LC(50) = 1.29) > Balanites aegyptiaca (LC(50) = 7.1) > Xylia evansii (LC(50) = 11.14) > Jathropha multifida (LC(50) = 12.9) > Justicia flava (LC(50) = 22.9) > Anopyxis klaineana (LC(50) = 182.81) > Ximenia americana (LC(50) = 194.98) > Loranthus lecardii (LC(50) = 223.87) > Bridelia tenufolia (LC(50) = 309.03) > Zanthoxylium zanthoxyloides (LC(50) = 851.94). Phytochemicals, including alkaloids, tannins, triterpenes, saponins, phytosterols, and flavonoids were identified in the plants. The result of this study gives scientific credence to the traditional use of these plants in the treatment of schistosomiasis and proves that the rich botanical knowledge of medicinal plants provides an incredible starting point for the discovery of new anti-schistosomal drugs for the local population. Hindawi 2023-07-19 /pmc/articles/PMC10372336/ /pubmed/37520159 http://dx.doi.org/10.1155/2023/6707157 Text en Copyright © 2023 Evelyn Asante-Kwatia et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Asante-Kwatia, Evelyn Gyimah, Lord Forkuo, Arnold Donkor Anyan, William Kofi Gbemu, Makafui Adzo Armah, Francis Ackah Mensah, Abraham Yeboah Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana |
title | Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana |
title_full | Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana |
title_fullStr | Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana |
title_full_unstemmed | Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana |
title_short | Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana |
title_sort | ethnobotanical survey and cercaricidal activity screening of medicinal plants used for schistosomiasis treatment in atwima-nwabiagya district, ashanti region, ghana |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372336/ https://www.ncbi.nlm.nih.gov/pubmed/37520159 http://dx.doi.org/10.1155/2023/6707157 |
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