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Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses

Presynaptic plasticity is an activity-dependent change in the neurotransmitter release and plays a key role in dynamic modulation of synaptic strength. Particularly, presynaptic potentiation mediated by cyclic adenosine monophosphate (cAMP) is widely seen across the animals and thought to contribute...

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Autores principales: Fukaya, Ryota, Miyano, Rinako, Hirai, Himawari, Sakaba, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372368/
https://www.ncbi.nlm.nih.gov/pubmed/37519634
http://dx.doi.org/10.3389/fncel.2023.1237589
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author Fukaya, Ryota
Miyano, Rinako
Hirai, Himawari
Sakaba, Takeshi
author_facet Fukaya, Ryota
Miyano, Rinako
Hirai, Himawari
Sakaba, Takeshi
author_sort Fukaya, Ryota
collection PubMed
description Presynaptic plasticity is an activity-dependent change in the neurotransmitter release and plays a key role in dynamic modulation of synaptic strength. Particularly, presynaptic potentiation mediated by cyclic adenosine monophosphate (cAMP) is widely seen across the animals and thought to contribute to learning and memory. Hippocampal mossy fiber-CA3 pyramidal cell synapses have been used as a model because of robust presynaptic potentiation in short- and long-term forms. Moreover, direct presynaptic recordings from large mossy fiber terminals allow one to dissect the potentiation mechanisms. Recently, super-resolution microscopy and flash-and-freeze electron microscopy have revealed the localizations of release site molecules and synaptic vesicles during the potentiation at a nanoscale, identifying the molecular mechanisms of the potentiation. Incorporating these growing knowledges, we try to present plausible mechanisms underlying the cAMP-mediated presynaptic potentiation.
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spelling pubmed-103723682023-07-28 Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses Fukaya, Ryota Miyano, Rinako Hirai, Himawari Sakaba, Takeshi Front Cell Neurosci Neuroscience Presynaptic plasticity is an activity-dependent change in the neurotransmitter release and plays a key role in dynamic modulation of synaptic strength. Particularly, presynaptic potentiation mediated by cyclic adenosine monophosphate (cAMP) is widely seen across the animals and thought to contribute to learning and memory. Hippocampal mossy fiber-CA3 pyramidal cell synapses have been used as a model because of robust presynaptic potentiation in short- and long-term forms. Moreover, direct presynaptic recordings from large mossy fiber terminals allow one to dissect the potentiation mechanisms. Recently, super-resolution microscopy and flash-and-freeze electron microscopy have revealed the localizations of release site molecules and synaptic vesicles during the potentiation at a nanoscale, identifying the molecular mechanisms of the potentiation. Incorporating these growing knowledges, we try to present plausible mechanisms underlying the cAMP-mediated presynaptic potentiation. Frontiers Media S.A. 2023-07-13 /pmc/articles/PMC10372368/ /pubmed/37519634 http://dx.doi.org/10.3389/fncel.2023.1237589 Text en Copyright © 2023 Fukaya, Miyano, Hirai and Sakaba. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Fukaya, Ryota
Miyano, Rinako
Hirai, Himawari
Sakaba, Takeshi
Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses
title Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses
title_full Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses
title_fullStr Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses
title_full_unstemmed Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses
title_short Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses
title_sort mechanistic insights into camp-mediated presynaptic potentiation at hippocampal mossy fiber synapses
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372368/
https://www.ncbi.nlm.nih.gov/pubmed/37519634
http://dx.doi.org/10.3389/fncel.2023.1237589
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