The effect of histone deacetylase inhibitors on the efficiency of the CRISPR/Cas9 system

The CRISPR/Cas9 technology is a prominent genome-editing tool capable of producing a double-strand break in the genome. However, the modification of hematopoietic stem cells via the homology-directed repair pathway is still inefficient. Therefore, we hypothesize that histone deacetylase inhibitors,...

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Detalles Bibliográficos
Autores principales: Björnson, Ymer, Huang, Codey Y., Rollins, Jaedyn L., Castañeda, Guadalupe, Kaur, Navneet, Yamamoto, Emiko, Johnston, Jennifer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372373/
https://www.ncbi.nlm.nih.gov/pubmed/37521376
http://dx.doi.org/10.1016/j.bbrep.2023.101513

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