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Onset of Guillain-Barre Syndrome and Transverse Myelitis Following COVID-19 Vaccination

Guillain-Barre syndrome (GBS) and transverse myelitis (TM) are both neuro-inflammatory disorders that are attributed to dysfunctions of the peripheral nervous system and spinal cord, respectively. The two conditions involve immune-mediated destruction and inflammation of the nervous system and may p...

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Autores principales: Do, Kenny, Kawana, Eric, Do, Jenifer, Diaz, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372383/
https://www.ncbi.nlm.nih.gov/pubmed/37519513
http://dx.doi.org/10.7759/cureus.41009
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author Do, Kenny
Kawana, Eric
Do, Jenifer
Diaz, Luis
author_facet Do, Kenny
Kawana, Eric
Do, Jenifer
Diaz, Luis
author_sort Do, Kenny
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description Guillain-Barre syndrome (GBS) and transverse myelitis (TM) are both neuro-inflammatory disorders that are attributed to dysfunctions of the peripheral nervous system and spinal cord, respectively. The two conditions involve immune-mediated destruction and inflammation of the nervous system and may present clinically as a weakness in the muscles, loss of normal sensations, and even paralysis of the body or extremities. Although the incidence of GBS and TM is quite rare, there have been reports of the two diseases developing in patients, either independently or concurrently, following COVID-19 vaccinations. In this case report, we present a patient (male) who lost functions and sensations in his lower extremities 60 days after he received the COVID-19 booster vaccine. The patient’s blood work was unremarkable. Magnetic resonance imaging (MRI) of his thoracic spine and an electromyography study revealed evidence of nerve demyelination, which supports the diagnosis of GBS/TM overlap syndrome. He was ultimately treated with intravenous immunoglobulins (IVIGs) and gained back functions in his lower extremities.
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spelling pubmed-103723832023-07-28 Onset of Guillain-Barre Syndrome and Transverse Myelitis Following COVID-19 Vaccination Do, Kenny Kawana, Eric Do, Jenifer Diaz, Luis Cureus Internal Medicine Guillain-Barre syndrome (GBS) and transverse myelitis (TM) are both neuro-inflammatory disorders that are attributed to dysfunctions of the peripheral nervous system and spinal cord, respectively. The two conditions involve immune-mediated destruction and inflammation of the nervous system and may present clinically as a weakness in the muscles, loss of normal sensations, and even paralysis of the body or extremities. Although the incidence of GBS and TM is quite rare, there have been reports of the two diseases developing in patients, either independently or concurrently, following COVID-19 vaccinations. In this case report, we present a patient (male) who lost functions and sensations in his lower extremities 60 days after he received the COVID-19 booster vaccine. The patient’s blood work was unremarkable. Magnetic resonance imaging (MRI) of his thoracic spine and an electromyography study revealed evidence of nerve demyelination, which supports the diagnosis of GBS/TM overlap syndrome. He was ultimately treated with intravenous immunoglobulins (IVIGs) and gained back functions in his lower extremities. Cureus 2023-06-26 /pmc/articles/PMC10372383/ /pubmed/37519513 http://dx.doi.org/10.7759/cureus.41009 Text en Copyright © 2023, Do et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Do, Kenny
Kawana, Eric
Do, Jenifer
Diaz, Luis
Onset of Guillain-Barre Syndrome and Transverse Myelitis Following COVID-19 Vaccination
title Onset of Guillain-Barre Syndrome and Transverse Myelitis Following COVID-19 Vaccination
title_full Onset of Guillain-Barre Syndrome and Transverse Myelitis Following COVID-19 Vaccination
title_fullStr Onset of Guillain-Barre Syndrome and Transverse Myelitis Following COVID-19 Vaccination
title_full_unstemmed Onset of Guillain-Barre Syndrome and Transverse Myelitis Following COVID-19 Vaccination
title_short Onset of Guillain-Barre Syndrome and Transverse Myelitis Following COVID-19 Vaccination
title_sort onset of guillain-barre syndrome and transverse myelitis following covid-19 vaccination
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372383/
https://www.ncbi.nlm.nih.gov/pubmed/37519513
http://dx.doi.org/10.7759/cureus.41009
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