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Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities

In recent years, a paradigm shift in neuroscience has been occurring from “localizationism,” or the idea that the brain is organized into separately functioning modules, toward “connectomics,” or the idea that interconnected nodes form networks as the underlying substrates of behavior and thought. A...

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Autores principales: Boerger, Timothy F., Pahapill, Peter, Butts, Alissa M., Arocho-Quinones, Elsa, Raghavan, Manoj, Krucoff, Max O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372448/
https://www.ncbi.nlm.nih.gov/pubmed/37520929
http://dx.doi.org/10.3389/fnhum.2023.1170419
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author Boerger, Timothy F.
Pahapill, Peter
Butts, Alissa M.
Arocho-Quinones, Elsa
Raghavan, Manoj
Krucoff, Max O.
author_facet Boerger, Timothy F.
Pahapill, Peter
Butts, Alissa M.
Arocho-Quinones, Elsa
Raghavan, Manoj
Krucoff, Max O.
author_sort Boerger, Timothy F.
collection PubMed
description In recent years, a paradigm shift in neuroscience has been occurring from “localizationism,” or the idea that the brain is organized into separately functioning modules, toward “connectomics,” or the idea that interconnected nodes form networks as the underlying substrates of behavior and thought. Accordingly, our understanding of mechanisms of neurological function, dysfunction, and recovery has evolved to include connections, disconnections, and reconnections. Brain tumors provide a unique opportunity to probe large-scale neural networks with focal and sometimes reversible lesions, allowing neuroscientists the unique opportunity to directly test newly formed hypotheses about underlying brain structural-functional relationships and network properties. Moreover, if a more complete model of neurological dysfunction is to be defined as a “disconnectome,” potential avenues for recovery might be mapped through a “reconnectome.” Such insight may open the door to novel therapeutic approaches where previous attempts have failed. In this review, we briefly delve into the most clinically relevant neural networks and brain mapping techniques, and we examine how they are being applied to modern neurosurgical brain tumor practices. We then explore how brain tumors might teach us more about mechanisms of global brain dysfunction and recovery through pre- and postoperative longitudinal connectomic and behavioral analyses.
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spelling pubmed-103724482023-07-28 Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities Boerger, Timothy F. Pahapill, Peter Butts, Alissa M. Arocho-Quinones, Elsa Raghavan, Manoj Krucoff, Max O. Front Hum Neurosci Neuroscience In recent years, a paradigm shift in neuroscience has been occurring from “localizationism,” or the idea that the brain is organized into separately functioning modules, toward “connectomics,” or the idea that interconnected nodes form networks as the underlying substrates of behavior and thought. Accordingly, our understanding of mechanisms of neurological function, dysfunction, and recovery has evolved to include connections, disconnections, and reconnections. Brain tumors provide a unique opportunity to probe large-scale neural networks with focal and sometimes reversible lesions, allowing neuroscientists the unique opportunity to directly test newly formed hypotheses about underlying brain structural-functional relationships and network properties. Moreover, if a more complete model of neurological dysfunction is to be defined as a “disconnectome,” potential avenues for recovery might be mapped through a “reconnectome.” Such insight may open the door to novel therapeutic approaches where previous attempts have failed. In this review, we briefly delve into the most clinically relevant neural networks and brain mapping techniques, and we examine how they are being applied to modern neurosurgical brain tumor practices. We then explore how brain tumors might teach us more about mechanisms of global brain dysfunction and recovery through pre- and postoperative longitudinal connectomic and behavioral analyses. Frontiers Media S.A. 2023-07-13 /pmc/articles/PMC10372448/ /pubmed/37520929 http://dx.doi.org/10.3389/fnhum.2023.1170419 Text en Copyright © 2023 Boerger, Pahapill, Butts, Arocho-Quinones, Raghavan and Krucoff. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Boerger, Timothy F.
Pahapill, Peter
Butts, Alissa M.
Arocho-Quinones, Elsa
Raghavan, Manoj
Krucoff, Max O.
Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities
title Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities
title_full Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities
title_fullStr Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities
title_full_unstemmed Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities
title_short Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities
title_sort large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372448/
https://www.ncbi.nlm.nih.gov/pubmed/37520929
http://dx.doi.org/10.3389/fnhum.2023.1170419
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