MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control

There remains an urgent need for new therapies for treatment-resistant epilepsy. Sodium channel blockers are effective for seizure control in common forms of epilepsy, but loss of sodium channel function underlies some genetic forms of epilepsy. Approaches that provide bidirectional control of sodiu...

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Detalles Bibliográficos
Autores principales: Heiland, Mona, Connolly, Niamh M. C., Mamad, Omar, Nguyen, Ngoc T., Kesavan, Jaideep C., Langa, Elena, Fanning, Kevin, Sanfeliu, Albert, Yan, Yan, Su, Junyi, Venø, Morten T., Costard, Lara S., Neubert, Valentin, Engel, Tobias, Hill, Thomas D. M., Freiman, Thomas M., Mahesh, Arun, Tiwari, Vijay K., Rosenow, Felix, Bauer, Sebastian, Kjems, Jørgen, Morris, Gareth, Henshall, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372546/
https://www.ncbi.nlm.nih.gov/pubmed/37463203
http://dx.doi.org/10.1073/pnas.2216658120

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