MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience

We first used MucoUp®, a hyaluronic acid used in endoscopic resection, as a spacer in brachytherapy. In five cervical cancer patients, MucoUp® insertion increased a 90% dose of the high-risk CTV to over 80 Gy while decreasing the dose of organs at risk. No related adverse events were observed.

Detalles Bibliográficos
Autores principales: Muramoto, Yoichi, Murakami, Naoya, Karino, Tatsuki, Sugimoto, Satoru, Takatsu, Jun, Oshima, Masaki, Kosugi, Yasuo, Kawamoto, Terufumi, Hirayama, Takashi, Fujino, Kazunari, Terao, Yasuhisa, Shikama, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372547/
https://www.ncbi.nlm.nih.gov/pubmed/37519921
http://dx.doi.org/10.1016/j.ctro.2023.100659
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author Muramoto, Yoichi
Murakami, Naoya
Karino, Tatsuki
Sugimoto, Satoru
Takatsu, Jun
Oshima, Masaki
Kosugi, Yasuo
Kawamoto, Terufumi
Hirayama, Takashi
Fujino, Kazunari
Terao, Yasuhisa
Shikama, Naoto
author_facet Muramoto, Yoichi
Murakami, Naoya
Karino, Tatsuki
Sugimoto, Satoru
Takatsu, Jun
Oshima, Masaki
Kosugi, Yasuo
Kawamoto, Terufumi
Hirayama, Takashi
Fujino, Kazunari
Terao, Yasuhisa
Shikama, Naoto
author_sort Muramoto, Yoichi
collection PubMed
description We first used MucoUp®, a hyaluronic acid used in endoscopic resection, as a spacer in brachytherapy. In five cervical cancer patients, MucoUp® insertion increased a 90% dose of the high-risk CTV to over 80 Gy while decreasing the dose of organs at risk. No related adverse events were observed.
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spelling pubmed-103725472023-07-28 MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience Muramoto, Yoichi Murakami, Naoya Karino, Tatsuki Sugimoto, Satoru Takatsu, Jun Oshima, Masaki Kosugi, Yasuo Kawamoto, Terufumi Hirayama, Takashi Fujino, Kazunari Terao, Yasuhisa Shikama, Naoto Clin Transl Radiat Oncol Short Communication We first used MucoUp®, a hyaluronic acid used in endoscopic resection, as a spacer in brachytherapy. In five cervical cancer patients, MucoUp® insertion increased a 90% dose of the high-risk CTV to over 80 Gy while decreasing the dose of organs at risk. No related adverse events were observed. Elsevier 2023-07-17 /pmc/articles/PMC10372547/ /pubmed/37519921 http://dx.doi.org/10.1016/j.ctro.2023.100659 Text en © 2023 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Muramoto, Yoichi
Murakami, Naoya
Karino, Tatsuki
Sugimoto, Satoru
Takatsu, Jun
Oshima, Masaki
Kosugi, Yasuo
Kawamoto, Terufumi
Hirayama, Takashi
Fujino, Kazunari
Terao, Yasuhisa
Shikama, Naoto
MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience
title MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience
title_full MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience
title_fullStr MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience
title_full_unstemmed MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience
title_short MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience
title_sort mucoup® as a spacer in brachytherapy for uterine cervical cancer: a first-in-human experience
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372547/
https://www.ncbi.nlm.nih.gov/pubmed/37519921
http://dx.doi.org/10.1016/j.ctro.2023.100659
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