Combination of the LARS1 Inhibitor, BC-LI-0186 with a MEK1/2 Inhibitor Enhances the Anti-Tumor Effect in Non–Small Cell Lung Cancer

PURPOSE: The mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth and proliferation by growth factor coordination and amino acid availability. Leucyl-tRNA synthetase 1 (LARS1) senses the intracellular leucine concentration and mediates amino acid-induced activation of mTORC1. Thus,...

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Detalles Bibliográficos
Autores principales: Lee, Sang Hoon, Kim, Eun Young, Han, Jung Min, Han, Gyoonhee, Chang, Yoon Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372589/
https://www.ncbi.nlm.nih.gov/pubmed/36960627
http://dx.doi.org/10.4143/crt.2022.1527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372589/
https://www.ncbi.nlm.nih.gov/pubmed/36960627
http://dx.doi.org/10.4143/crt.2022.1527

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