Identification of Genes Involved in EGF-Induced Apoptosis Using CRISPR/Cas9 Knockout Screening: Implications for Novel Therapeutic Targets in EGFR-Overexpressing Cancers

PURPOSE: Exogenous epidermal growth factor (EGF) causes apoptosis in EGF receptor (EGFR)–overexpressing cell lines. The apoptosis-inducing factors could be a therapeutic target. We aimed to determine the mechanism of EGF-induced apoptosis using a genome-wide clustered regularly interspaced short pal...

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Detalles Bibliográficos
Autores principales: Kim, Jae Sik, Lee, Joo Ho, Jeon, Sang-Rok, Kim, Yongsub, Jeon, Seung Hyuck, Wu, Hong-Gyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372596/
https://www.ncbi.nlm.nih.gov/pubmed/36596724
http://dx.doi.org/10.4143/crt.2022.1414

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