Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia

Pseudomonas aeruginosa (PA) CbpD belongs to the lytic polysaccharide monooxygenases (LPMOs), a family of enzymes that cleave chitin or related polysaccharides. Here, we demonstrate a virulence role of CbpD in PA pneumonia linked to impairment of host complement function and opsonophagocytic clearanc...

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Detalles Bibliográficos
Autores principales: Askarian, Fatemeh, Tsai, Chih-Ming, Cordara, Gabriele, Zurich, Raymond H., Bjånes, Elisabet, Golten, Ole, Vinther Sørensen, Henrik, Kousha, Armin, Meier, Angela, Chikwati, Elvis, Bruun, Jack-Ansgar, Ludviksen, Judith Anita, Choudhury, Biswa, Trieu, Desmond, Davis, Stanley, Edvardsen, Per Kristian Thorén, Mollnes, Tom Eirik, Liu, George Y., Krengel, Ute, Conrad, Douglas J., Vaaje-Kolstad, Gustav, Nizet, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372616/
https://www.ncbi.nlm.nih.gov/pubmed/37459522
http://dx.doi.org/10.1073/pnas.2301538120

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