IL-7R licenses a population of epigenetically poised memory CD8(+) T cells with superior antitumor efficacy that are critical for melanoma memory

Recurrence of advanced melanoma after therapy is a major risk factor for reduced survival, and treatment options are limited. Antitumor immune memory plays a critical role in preventing melanoma recurrence and memory T cells could be a potent cell-based therapy, but the identity, and functional prop...

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Detalles Bibliográficos
Autores principales: Micevic, Goran, Daniels, Andrew, Flem-Karlsen, Karine, Park, Koonam, Talty, Ronan, McGeary, Meaghan, Mirza, Haris, Blackburn, Holly N., Sefik, Esen, Cheung, Julie F., Hornick, Noah I., Aizenbud, Lilach, Joshi, Nikhil S., Kluger, Harriet, Iwasaki, Akiko, Bosenberg, Marcus W., Flavell, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372654/
https://www.ncbi.nlm.nih.gov/pubmed/37459511
http://dx.doi.org/10.1073/pnas.2304319120

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