T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity

Aquaporin-4 (AQP4)-specific Th17 cells are thought to have a central role in neuromyelitis optica (NMO) pathogenesis. When modeling NMO, only AQP4-reactive Th17 cells from AQP4-deficient (AQP4(−/−)), but not wild-type (WT) mice, caused CNS autoimmunity in recipient WT mice, indicating that a tightly...

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Detalles Bibliográficos
Autores principales: Sagan, Sharon A., Moinfar, Zahra, Moseley, Carson E., Dandekar, Ravi, Spencer, Collin M., Verkman, Alan S., Ottersen, Ole Petter, Sobel, Raymond A., Sidney, John, Sette, Alessandro, Anderson, Mark S., Steinman, Lawrence, Wilson, Michael R., Sabatino, Joseph J., Zamvil, Scott S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372680/
https://www.ncbi.nlm.nih.gov/pubmed/37463205
http://dx.doi.org/10.1073/pnas.2306572120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372680/
https://www.ncbi.nlm.nih.gov/pubmed/37463205
http://dx.doi.org/10.1073/pnas.2306572120

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