Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity

Cellular eukaryotic replication initiation helicases are first loaded as head-to-head double hexamers on double-stranded (ds) DNA origins and then initiate S-phase DNA melting during licensed (once per cell cycle) replication. Merkel cell polyomavirus (MCV) large T (LT) helicase oncoprotein similarl...

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Detalles Bibliográficos
Autores principales: Wan, Li, Toland, Sabrina, Robinson-McCarthy, Lindsey R., Lee, Nara, Schaich, Matthew A., Hengel, Sarah R., Li, Xiaochen, Bernstein, Kara A., Van Houten, Bennett, Chang, Yuan, Moore, Patrick S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372695/
https://www.ncbi.nlm.nih.gov/pubmed/37459531
http://dx.doi.org/10.1073/pnas.2308010120

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