An anthropomorphic body phantom for the determination of calibration factor in radionuclide treatment dosimetry

The aim of this study is to create an inhomogeneous human-like phantom, whose attenuation and scattering effects are similar to the human body, as an alternative to the homogeneous phantoms traditionally used in calibration factor (CF) determination. The phantom was designed to include the thorax, a...

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Autores principales: Kovan, Bilal, Demir, Bayram, Işık, Emine Göknur, Has Şimşek, Duygu, Özkan, Zeynep Gözde, Kuyumcu, Sekan, Türkmen, Cüneyt, Şanlı, Yasemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372715/
https://www.ncbi.nlm.nih.gov/pubmed/37334429
http://dx.doi.org/10.1093/rpd/ncad176
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author Kovan, Bilal
Demir, Bayram
Işık, Emine Göknur
Has Şimşek, Duygu
Özkan, Zeynep Gözde
Kuyumcu, Sekan
Türkmen, Cüneyt
Şanlı, Yasemin
author_facet Kovan, Bilal
Demir, Bayram
Işık, Emine Göknur
Has Şimşek, Duygu
Özkan, Zeynep Gözde
Kuyumcu, Sekan
Türkmen, Cüneyt
Şanlı, Yasemin
author_sort Kovan, Bilal
collection PubMed
description The aim of this study is to create an inhomogeneous human-like phantom, whose attenuation and scattering effects are similar to the human body, as an alternative to the homogeneous phantoms traditionally used in calibration factor (CF) determination. The phantom was designed to include the thorax, abdomen and upper pelvis regions sized to represent a 75-kg male with a body mass index of 25. Measurements using Lu-177 with 50- and 100-mL lesion volumes were performed using inhomogeneous anthropomorphic body phantom (ABP) and homogeneous NEMA PET body phantom. There was a difference of 5.7% of Calibration Factor including attenuation and scatter effect between ABP and NEMA PET body phantom. Because it better reflects the attenuation and scatter effect, it is recommended to use a human-like inhomogeneous phantom for determination of CF instead of a homogeneous phantom.
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spelling pubmed-103727152023-07-28 An anthropomorphic body phantom for the determination of calibration factor in radionuclide treatment dosimetry Kovan, Bilal Demir, Bayram Işık, Emine Göknur Has Şimşek, Duygu Özkan, Zeynep Gözde Kuyumcu, Sekan Türkmen, Cüneyt Şanlı, Yasemin Radiat Prot Dosimetry Paper The aim of this study is to create an inhomogeneous human-like phantom, whose attenuation and scattering effects are similar to the human body, as an alternative to the homogeneous phantoms traditionally used in calibration factor (CF) determination. The phantom was designed to include the thorax, abdomen and upper pelvis regions sized to represent a 75-kg male with a body mass index of 25. Measurements using Lu-177 with 50- and 100-mL lesion volumes were performed using inhomogeneous anthropomorphic body phantom (ABP) and homogeneous NEMA PET body phantom. There was a difference of 5.7% of Calibration Factor including attenuation and scatter effect between ABP and NEMA PET body phantom. Because it better reflects the attenuation and scatter effect, it is recommended to use a human-like inhomogeneous phantom for determination of CF instead of a homogeneous phantom. Oxford University Press 2023-06-17 /pmc/articles/PMC10372715/ /pubmed/37334429 http://dx.doi.org/10.1093/rpd/ncad176 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Paper
Kovan, Bilal
Demir, Bayram
Işık, Emine Göknur
Has Şimşek, Duygu
Özkan, Zeynep Gözde
Kuyumcu, Sekan
Türkmen, Cüneyt
Şanlı, Yasemin
An anthropomorphic body phantom for the determination of calibration factor in radionuclide treatment dosimetry
title An anthropomorphic body phantom for the determination of calibration factor in radionuclide treatment dosimetry
title_full An anthropomorphic body phantom for the determination of calibration factor in radionuclide treatment dosimetry
title_fullStr An anthropomorphic body phantom for the determination of calibration factor in radionuclide treatment dosimetry
title_full_unstemmed An anthropomorphic body phantom for the determination of calibration factor in radionuclide treatment dosimetry
title_short An anthropomorphic body phantom for the determination of calibration factor in radionuclide treatment dosimetry
title_sort anthropomorphic body phantom for the determination of calibration factor in radionuclide treatment dosimetry
topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372715/
https://www.ncbi.nlm.nih.gov/pubmed/37334429
http://dx.doi.org/10.1093/rpd/ncad176
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