Multimodal brain image fusion based on error texture elimination and salient feature detection

As an important clinically oriented information fusion technology, multimodal medical image fusion integrates useful information from different modal images into a comprehensive fused image. Nevertheless, existing methods routinely consider only energy information when fusing low-frequency or base layers, ignoring the fact that useful texture information may exist in pixels with lower energy values. Thus, erroneous textures may be introduced into the fusion results. To resolve this problem, we propose a novel multimodal brain image fusion algorithm based on error texture removal. A two-layer decomposition scheme is first implemented to generate the high- and low-frequency subbands. We propose a salient feature detection operator based on gradient difference and entropy. The proposed operator integrates the gradient difference and amount of information in the high-frequency subbands to effectively identify clearly detailed information. Subsequently, we detect the energy information of the low-frequency subband by utilizing the local phase feature of each pixel as the intensity measurement and using a random walk algorithm to detect the energy information. Finally, we propose a rolling guidance filtering iterative least-squares model to reconstruct the texture information in the low-frequency components. Through extensive experiments, we successfully demonstrate that the proposed algorithm outperforms some state-of-the-art methods. Our source code is publicly available at https://github.com/ixilai/ETEM.