Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs

A series of new monobactam sulfonates is continuously synthesized and evaluated for their antimicrobial efficacies against Gram-negative bacteria. Compound 33a (IMBZ18G) is highly effective in vitro and in vivo against clinically intractable multi-drug-resistant (MDR) Gram-negative strains, with a h...

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Detalles Bibliográficos
Autores principales: Li, Zhiwen, Guo, Zhihao, Lu, Xi, Ma, Xican, Wang, Xiukun, Zhang, Rui, Hu, Xinxin, Wang, Yanxiang, Pang, Jing, Fan, Tianyun, Liu, Yonghua, Tang, Sheng, Fu, Haigen, Zhang, Jingpu, Li, Yinghong, You, Xuefu, Song, Danqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372838/
https://www.ncbi.nlm.nih.gov/pubmed/37521870
http://dx.doi.org/10.1016/j.apsb.2023.03.002

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