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Phototriggered structures: Latest advances in biomedical applications
Non-invasive control of the drug molecules accessibility is a key issue in improving diagnostic and therapeutic procedures. Some studies have explored the spatiotemporal control by light as a peripheral stimulus. Phototriggered drug delivery systems (PTDDSs) have received interest in the past decade...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372844/ https://www.ncbi.nlm.nih.gov/pubmed/37521863 http://dx.doi.org/10.1016/j.apsb.2023.04.005 |
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author | Shamsipur, Mojtaba Ghavidast, Atefeh Pashabadi, Afshin |
author_facet | Shamsipur, Mojtaba Ghavidast, Atefeh Pashabadi, Afshin |
author_sort | Shamsipur, Mojtaba |
collection | PubMed |
description | Non-invasive control of the drug molecules accessibility is a key issue in improving diagnostic and therapeutic procedures. Some studies have explored the spatiotemporal control by light as a peripheral stimulus. Phototriggered drug delivery systems (PTDDSs) have received interest in the past decade among biological researchers due to their capability the control drug release. To this end, a wide range of phototrigger molecular structures participated in the DDSs to serve additional efficiency and a high-conversion release of active fragments under light irradiation. Up to now, several categories of PTDDSs have been extended to upgrade the performance of controlled delivery of therapeutic agents based on well-known phototrigger molecular structures like o-nitrobenzyl, coumarinyl, anthracenyl, quinolinyl, o-hydroxycinnamate and hydroxyphenacyl, where either of one endows an exclusive feature and distinct mechanistic approach. This review conveys the design, photochemical properties and essential mechanism of the most important phototriggered structures for the release of single and dual (similar or different) active molecules that have the ability to quickly reason of the large variety of dynamic biological phenomena for biomedical applications like photo-regulated drug release, synergistic outcomes, real-time monitoring, and biocompatibility potential. |
format | Online Article Text |
id | pubmed-10372844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103728442023-07-28 Phototriggered structures: Latest advances in biomedical applications Shamsipur, Mojtaba Ghavidast, Atefeh Pashabadi, Afshin Acta Pharm Sin B Review Non-invasive control of the drug molecules accessibility is a key issue in improving diagnostic and therapeutic procedures. Some studies have explored the spatiotemporal control by light as a peripheral stimulus. Phototriggered drug delivery systems (PTDDSs) have received interest in the past decade among biological researchers due to their capability the control drug release. To this end, a wide range of phototrigger molecular structures participated in the DDSs to serve additional efficiency and a high-conversion release of active fragments under light irradiation. Up to now, several categories of PTDDSs have been extended to upgrade the performance of controlled delivery of therapeutic agents based on well-known phototrigger molecular structures like o-nitrobenzyl, coumarinyl, anthracenyl, quinolinyl, o-hydroxycinnamate and hydroxyphenacyl, where either of one endows an exclusive feature and distinct mechanistic approach. This review conveys the design, photochemical properties and essential mechanism of the most important phototriggered structures for the release of single and dual (similar or different) active molecules that have the ability to quickly reason of the large variety of dynamic biological phenomena for biomedical applications like photo-regulated drug release, synergistic outcomes, real-time monitoring, and biocompatibility potential. Elsevier 2023-07 2023-04-17 /pmc/articles/PMC10372844/ /pubmed/37521863 http://dx.doi.org/10.1016/j.apsb.2023.04.005 Text en © 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Shamsipur, Mojtaba Ghavidast, Atefeh Pashabadi, Afshin Phototriggered structures: Latest advances in biomedical applications |
title | Phototriggered structures: Latest advances in biomedical applications |
title_full | Phototriggered structures: Latest advances in biomedical applications |
title_fullStr | Phototriggered structures: Latest advances in biomedical applications |
title_full_unstemmed | Phototriggered structures: Latest advances in biomedical applications |
title_short | Phototriggered structures: Latest advances in biomedical applications |
title_sort | phototriggered structures: latest advances in biomedical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372844/ https://www.ncbi.nlm.nih.gov/pubmed/37521863 http://dx.doi.org/10.1016/j.apsb.2023.04.005 |
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