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Structural Characterization of Cu(I)/Zn(II)-metallothionein-3 by Ion Mobility Mass Spectrometry and Top-Down Mass Spectrometry

[Image: see text] Mammalian zinc metallothionein-3 (Zn(7)MT3) plays an important role in protecting against copper toxicity by scavenging free Cu(II) ions or removing Cu(II) bound to β-amyloid and α-synuclein. While previous studies reported that Zn(7)MT3 reacts with Cu(II) ions to form Cu(I)(4)Zn(I...

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Detalles Bibliográficos
Autores principales:	Peris-Díaz, Manuel David, Wu, Sylwia, Mosna, Karolina, Liggett, Ellen, Barkhanskiy, Alexey, Orzeł, Alicja, Barran, Perdita, Krężel, Artur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372872/ https://www.ncbi.nlm.nih.gov/pubmed/37440218 http://dx.doi.org/10.1021/acs.analchem.3c00989

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