Activation of Sphingomyelin Phosphodiesterase 3 in Liver Regeneration Impedes the Progression of Colorectal Cancer Liver Metastasis Via Exosome-Bound Intercellular Transfer of Ceramides

BACKGROUND & AIMS: The machinery that prevents colorectal cancer liver metastasis (CRLM) in the context of liver regeneration (LR) remains elusive. Ceramide (CER) is a potent anti-cancer lipid involved in intercellular interaction. Here, we investigated the role of CER metabolism in mediating th...

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Detalles Bibliográficos
Autores principales: Li, Qingping, Li, Jieyuan, Wang, Kai, Liao, Leyi, Li, Yiyi, Liang, Hanbiao, Huang, Can, Gan, Jian, Dong, Xiaoyu, Hu, Yaowen, Cheng, Jiaxin, Ji, Hongli, Liu, Cuiting, Zeng, Minghui, Yu, Sheng, Wang, Biao, Qian, Jianping, Tang, Zhongshun, Peng, Yonghong, Tang, Shanhua, Li, Mengxuan, Zhou, Jie, Yan, Jun, Li, Chuanjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372907/
https://www.ncbi.nlm.nih.gov/pubmed/37245564
http://dx.doi.org/10.1016/j.jcmgh.2023.05.007

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