Cancer-associated fibroblasts drive CXCL13 production in activated T cells via TGF-beta

INTRODUCTION: Tumour-reactive T cells producing the B-cell attractant chemokine CXCL13, in solid tumours, promote development of tertiary lymphoid structures (TLS) and are associated with improved prognosis and responsiveness to checkpoint immunotherapy. Cancer associated fibroblasts are the dominan...

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Detalles Bibliográficos
Autores principales: O’Connor, Richard A., Martinez, Begoña Roman, Koppensteiner, Lilian, Mathieson, Layla, Akram, Ahsan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373066/
https://www.ncbi.nlm.nih.gov/pubmed/37520560
http://dx.doi.org/10.3389/fimmu.2023.1221532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373066/
https://www.ncbi.nlm.nih.gov/pubmed/37520560
http://dx.doi.org/10.3389/fimmu.2023.1221532

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