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Application of neurotransmitters and dental stem cells for pulp regeneration: A review

INTRODUCTION: Although there have been many studies on stem cells, few have investigated how neurotransmitters and stem cell proliferation interact to regenerate dental pulp. Dental pulp regeneration is an innovative procedure for reviving dental pulp, if feasible for the entire tooth. Upon tooth in...

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Detalles Bibliográficos
Autores principales: Ramli, Hidayah, Yusop, Norhayati, Ramli, Rosmaliza, Berahim, Zurairah, Peiris, Roshan, Ghani, Nurhafizah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373085/
https://www.ncbi.nlm.nih.gov/pubmed/37520592
http://dx.doi.org/10.1016/j.sdentj.2023.05.004
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author Ramli, Hidayah
Yusop, Norhayati
Ramli, Rosmaliza
Berahim, Zurairah
Peiris, Roshan
Ghani, Nurhafizah
author_facet Ramli, Hidayah
Yusop, Norhayati
Ramli, Rosmaliza
Berahim, Zurairah
Peiris, Roshan
Ghani, Nurhafizah
author_sort Ramli, Hidayah
collection PubMed
description INTRODUCTION: Although there have been many studies on stem cells, few have investigated how neurotransmitters and stem cell proliferation interact to regenerate dental pulp. Dental pulp regeneration is an innovative procedure for reviving dental pulp, if feasible for the entire tooth. Upon tooth injury, activated platelets release serotonin and dopamine in bulk to mobilize dental pulp stem cells to mediate natural dental repair. This has induced research on the role of neurotransmitters in increasing the proliferation rate of stem cells. This review also covers prospective future treatments for dental pulp regeneration. METHODS: A literature search was performed via PubMed and ScienceDirect from 2001 to 2022, using the keywords “neurotransmitter,” “stem cell,” “tooth regeneration,” “tooth repair,” “regenerative dentistry,” and “dental pulp.” Different inclusion/exclusion criteria were used, and the search was restricted to English articles. RESULTS: Nine publications reporting neurotransmitter interactions with stem cells for tooth and pulp regeneration were selected. CONCLUSION: Neurotransmitters were found to interact with dental stem cells. Evidence pointing to neurotransmitters as a factor in the increased proliferation of stem cells was found. This review thus gives hope for tooth pulp regeneration and repair.
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spelling pubmed-103730852023-07-28 Application of neurotransmitters and dental stem cells for pulp regeneration: A review Ramli, Hidayah Yusop, Norhayati Ramli, Rosmaliza Berahim, Zurairah Peiris, Roshan Ghani, Nurhafizah Saudi Dent J Review Article INTRODUCTION: Although there have been many studies on stem cells, few have investigated how neurotransmitters and stem cell proliferation interact to regenerate dental pulp. Dental pulp regeneration is an innovative procedure for reviving dental pulp, if feasible for the entire tooth. Upon tooth injury, activated platelets release serotonin and dopamine in bulk to mobilize dental pulp stem cells to mediate natural dental repair. This has induced research on the role of neurotransmitters in increasing the proliferation rate of stem cells. This review also covers prospective future treatments for dental pulp regeneration. METHODS: A literature search was performed via PubMed and ScienceDirect from 2001 to 2022, using the keywords “neurotransmitter,” “stem cell,” “tooth regeneration,” “tooth repair,” “regenerative dentistry,” and “dental pulp.” Different inclusion/exclusion criteria were used, and the search was restricted to English articles. RESULTS: Nine publications reporting neurotransmitter interactions with stem cells for tooth and pulp regeneration were selected. CONCLUSION: Neurotransmitters were found to interact with dental stem cells. Evidence pointing to neurotransmitters as a factor in the increased proliferation of stem cells was found. This review thus gives hope for tooth pulp regeneration and repair. Elsevier 2023-07 2023-05-12 /pmc/articles/PMC10373085/ /pubmed/37520592 http://dx.doi.org/10.1016/j.sdentj.2023.05.004 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Ramli, Hidayah
Yusop, Norhayati
Ramli, Rosmaliza
Berahim, Zurairah
Peiris, Roshan
Ghani, Nurhafizah
Application of neurotransmitters and dental stem cells for pulp regeneration: A review
title Application of neurotransmitters and dental stem cells for pulp regeneration: A review
title_full Application of neurotransmitters and dental stem cells for pulp regeneration: A review
title_fullStr Application of neurotransmitters and dental stem cells for pulp regeneration: A review
title_full_unstemmed Application of neurotransmitters and dental stem cells for pulp regeneration: A review
title_short Application of neurotransmitters and dental stem cells for pulp regeneration: A review
title_sort application of neurotransmitters and dental stem cells for pulp regeneration: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373085/
https://www.ncbi.nlm.nih.gov/pubmed/37520592
http://dx.doi.org/10.1016/j.sdentj.2023.05.004
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