CDK2 regulates collapsed replication fork repair in CCNE1-amplified ovarian cancer cells via homologous recombination

CCNE1 amplification is a common alteration in high-grade serous ovarian cancer and occurs in 15–20% of these tumors. These amplifications are mutually exclusive with homologous recombination deficiency, and, as they have intact homologous recombination, are intrinsically resistant to poly (ADP-ribos...

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Detalles Bibliográficos
Autores principales: Brown, Victoria E, Moore, Sydney L, Chen, Maxine, House, Nealia, Ramsden, Philip, Wu, Hsin-Jung, Ribich, Scott, Grassian, Alexandra R, Choi, Yoon Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373114/
https://www.ncbi.nlm.nih.gov/pubmed/37519629
http://dx.doi.org/10.1093/narcan/zcad039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373114/
https://www.ncbi.nlm.nih.gov/pubmed/37519629
http://dx.doi.org/10.1093/narcan/zcad039

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