Cytosporones W and X: Two Mutually Converting Epimers from a Mangrove Endophytic Fungus Diaporthe sp. ZJHJYZ-1

[Image: see text] Two new octaketides, cytosporones W (1) and X (2), along with eight known cytosporone derivatives [(±)-3–9], were isolated from mangrove endophytic fungus Diaporthe sp. ZJHJYZ-1. Compounds 1 and 2 were a pair of epimers, whose configuration of C-1 could mutually convert, causing ra...

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Autores principales: Yin, Yihao, Yang, Wencong, Chen, Tao, Tan, Qi, Zou, Ge, Zang, Zhenming, Li, Jiehui, Wang, Bo, She, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373200/
https://www.ncbi.nlm.nih.gov/pubmed/37521628
http://dx.doi.org/10.1021/acsomega.3c03862
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author Yin, Yihao
Yang, Wencong
Chen, Tao
Tan, Qi
Zou, Ge
Zang, Zhenming
Li, Jiehui
Wang, Bo
She, Zhigang
author_facet Yin, Yihao
Yang, Wencong
Chen, Tao
Tan, Qi
Zou, Ge
Zang, Zhenming
Li, Jiehui
Wang, Bo
She, Zhigang
author_sort Yin, Yihao
collection PubMed
description [Image: see text] Two new octaketides, cytosporones W (1) and X (2), along with eight known cytosporone derivatives [(±)-3–9], were isolated from mangrove endophytic fungus Diaporthe sp. ZJHJYZ-1. Compounds 1 and 2 were a pair of epimers, whose configuration of C-1 could mutually convert, causing racemization of the lactone ring. The planar structures of compounds were elucidated through detailed 1D, 2D NMR, and HR-ESI-MS analysis. ECD spectra comparison and modified Mosher ester method were applied to determine the absolute configuration of 1 and 2. In bioassays, (±)-3 exhibited promising inhibitory activities against Bacillus subtilis, Pseudomonas aeruginosa, and Penicillium italicum with MIC, respectively, for 12.5, 12.5, and 3.13 μM.
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spelling pubmed-103732002023-07-28 Cytosporones W and X: Two Mutually Converting Epimers from a Mangrove Endophytic Fungus Diaporthe sp. ZJHJYZ-1 Yin, Yihao Yang, Wencong Chen, Tao Tan, Qi Zou, Ge Zang, Zhenming Li, Jiehui Wang, Bo She, Zhigang ACS Omega [Image: see text] Two new octaketides, cytosporones W (1) and X (2), along with eight known cytosporone derivatives [(±)-3–9], were isolated from mangrove endophytic fungus Diaporthe sp. ZJHJYZ-1. Compounds 1 and 2 were a pair of epimers, whose configuration of C-1 could mutually convert, causing racemization of the lactone ring. The planar structures of compounds were elucidated through detailed 1D, 2D NMR, and HR-ESI-MS analysis. ECD spectra comparison and modified Mosher ester method were applied to determine the absolute configuration of 1 and 2. In bioassays, (±)-3 exhibited promising inhibitory activities against Bacillus subtilis, Pseudomonas aeruginosa, and Penicillium italicum with MIC, respectively, for 12.5, 12.5, and 3.13 μM. American Chemical Society 2023-07-10 /pmc/articles/PMC10373200/ /pubmed/37521628 http://dx.doi.org/10.1021/acsomega.3c03862 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Yin, Yihao
Yang, Wencong
Chen, Tao
Tan, Qi
Zou, Ge
Zang, Zhenming
Li, Jiehui
Wang, Bo
She, Zhigang
Cytosporones W and X: Two Mutually Converting Epimers from a Mangrove Endophytic Fungus Diaporthe sp. ZJHJYZ-1
title Cytosporones W and X: Two Mutually Converting Epimers from a Mangrove Endophytic Fungus Diaporthe sp. ZJHJYZ-1
title_full Cytosporones W and X: Two Mutually Converting Epimers from a Mangrove Endophytic Fungus Diaporthe sp. ZJHJYZ-1
title_fullStr Cytosporones W and X: Two Mutually Converting Epimers from a Mangrove Endophytic Fungus Diaporthe sp. ZJHJYZ-1
title_full_unstemmed Cytosporones W and X: Two Mutually Converting Epimers from a Mangrove Endophytic Fungus Diaporthe sp. ZJHJYZ-1
title_short Cytosporones W and X: Two Mutually Converting Epimers from a Mangrove Endophytic Fungus Diaporthe sp. ZJHJYZ-1
title_sort cytosporones w and x: two mutually converting epimers from a mangrove endophytic fungus diaporthe sp. zjhjyz-1
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373200/
https://www.ncbi.nlm.nih.gov/pubmed/37521628
http://dx.doi.org/10.1021/acsomega.3c03862
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